Lecture 4 Flashcards
(43 cards)
what is the order of the cell cycle
- G1 phase
- S phase DNA replication
- G2 phase
- M phase mitosis and cytokinesis
during what stage does DNA replication happen
interphase
when does mitosis happen
M phase
when does cytokinesis happen
m phase
what are the stages of mitosis
- prophase
- prometaphase
- metaphase
- anaphase
- telophase
what is comprised within interphase
- G1
- S
- G2
what does flank mean
on either side
true/false the cell cycle is present and regulated in all organisms
true
during which stages does cell growth occur
at all phases EXCEPT during mitosis
how much of the cell cycle does mitosis take up
5-10%
true/false lots of cells are in G0
true
M phase is flanked by which 2 phases
G1 and G2
when are the 3 major checkpoints in the cell cycle
- start checkpoint in G1/S
- G2/M checkpoint
- metaphase/ anaphase checkpoint
what does the G1/S checkpoint look for
is environment favourable?
what does the G2/M checkpoint look for
- is all DNA replicated
- is environment favourable
what does the metaphase/anaphase checkpoint look for
are all chromosomes attached to the spindle
if a cell passes the G1/S checkpoint, what can it do
enter cell cycle and proceed to S phase
if a cell passes the G2/M checkpoint, what can it do
enter mitosis
if a cell passes the metaphase/anaphase checkpoint, what can it do
trigger anaphase and proceed to cytokinesis
what do kinases do
add phosphate groups
true/false the kinase activity of each type of cyclin-Cdk complexes change as the cell progresses through the cell cycle
true
true/false the level of Cdks vary throughout the cell cycle
- false
- they remain relatively constant
- they just bind more when the levels of cyclins go up
true/false the level of cyclins vary throughout the cell cycle
true
where was the cell cycle originally studied
in yeast
