Lecture #4 Flashcards Preview

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Flashcards in Lecture #4 Deck (28):
1

Functions of the Circulatory System

1. Transport
2. Protection
3. Regulation

2

Components of Blood

Blood: a liquid connective tissue consisting of cells and extracellular martix
1. Plasma: matrix of the blood (yellow)
2. Formed elements: blood cell and cell fragments

4-6L

3

Hematocrit

1. Erythrocytes are heaviest and settle first 37% to 52% tv
2. White blood cells and platelets 1%tv
• Buffycoat
3. Plasma
• 47%to63%
• Complex mixture of water,
proteins, nutrients, hormones, gases

4

Blood Plasma

1. Plasma proteins
2. Nitrogenous compounds
3. Nutrients
4. Dissolved O2, CO2, and nitrogen
5. Electrolytes

5

Viscosity

resistance of fluid flow
4.5-5.5 more viscous than water

6

Osmolarity

Total molarity of dissolved particles that cannot pass through
the blood vessel wall

7

Formed Elements

1. Erythrocytes RBC
2. Platelets
3. Leukocytes WBC

8

Leukocytes contain

Granulocytes (with granules)
a) Neutrophils
b) Eosinophils
c) Basophils

Agranulocytes(w/out granules)
a) lymphocytes
b)Monocytes

9

Erythrocytes (RBC) Functions

1. Carry oxygen from lungs to cell tissues
2. pick up co2 from tissues to lungs

10

Hemoglobin

consist of 4 protein chains
2 a and 2b chains

11

Regulation of Erythropoiesis

-negative feedback control
- stimuli for erythropoiesis (production of RBC)

12

Hemolysis

Rupture of RBCs

13

Hemoglobin Disposal

Regulated to prevent kidney failure

14

Erythrocytes Disorders

Anemia = Deficiency In RBCs or hemoglobin

Polycythemia = excess RBCs

15

Causes of Iron Deficiency Anemia

Causes:
1. lack of iron intake
2. blood loss
3. metabolic iron deficiency

16

Antigens

Enables body to distinguish own cells from foreign(on surface of the cell)

17

Antibodies

binds antigens
destruction

18

Agglutination

bind 2 or more antigen molecules

19

Transfusion incompatibility

Karl Landsteiner (Nobel Prize)
Discovered blood types: A, B, and O

20

Hemostasis

the cessation of bleeding

21

Hemorrhage

excessive bledding

22

Hemostatic mechanisms

1. Vascular spasm (1st)
2. Platelet plug formation (2nd)
3. Blood clotting (coagulation) (3rd)

23

Platelet Form

small fragments of
megakaryocyte cells

Normal platelet count—130,000- 400,000 platelets/L

24

1st - Vascular Spasm

Prompt constriction of broken vessel

25

2nd - Platelet Plug formation

Platelet plug, Platelets bind, contract, pull walls of vessel
together

26

3rd - Coagulatin (clotting)

most effective
Objective: convert fibrinogen to fibrin
sticky protein–adheres to wall so vessels seal

27

Extrinsic

Initiated by clotting factors released from damaged blood vessel
• Fastest (2-6min)

28

Intrinsic

Initiated by
clotting factors in the blood (plasma or platelets)