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Neurogenetics > Lecture 4: Epigenetics & Gene Expression > Flashcards

Lecture 4: Epigenetics & Gene Expression Flashcards

1
Q

Mendelian Concept

Mendelian Genetics vs Epigenetics

A
  • Changes in DNA sequences are stably (forever) inhereted over generations
  • Inheritance is determined by genes which are intact and independently transmitted to the next generation
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2
Q

Epigenetics

Mendelian Genetics vs Epigenetics

A
  • Changes in gene expression caused by mechanisms
  • Not just changes in underlying DNA sequence
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3
Q

DNA Methylation

Role of Epigenetic Factors

A
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4
Q

Histone Acetylation & Methylation

Role of Epigenetic Factors

A
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5
Q

CpG Methylation

Role of Epigenetic Factors

A
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6
Q

How is DNA methylation generated?

DNA Methylation

A
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7
Q

How is DNA methylation used to silence gene expresion?

DNA Methylation

A
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8
Q

Constitutive heterochromatin

Types of Heterochromatin

A
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9
Q

Faculatative heterochromatin

Types of Heterochromatin

A
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10
Q

Transcriptionally permissive heterochromatin

Types of Heterochromatin

A
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11
Q

What is the developmental landscape of

5mCG levels

Developmental Landscape of Methylation Levels

A
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12
Q

What is the developmental landscape of

5mCH levels

Developmental Landscape of Methylation Levels

A
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13
Q

Variegation

Effects of Variegation & Variable Expressivity

A
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14
Q

Variable expressivity

Effects of Variegation & Variable Expressivity

A
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15
Q

What is variation in the agouti gene due to?

Variegation or variable expressivity?

A
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16
Q

What is the mottled phenoype of the yellow agouti gene?

A
17
Q

Intergenerational

Between or across generations? Is the germ line directly exposed?

Generational Inheritance

A

Between two generations
Germ line directly exposed (pregnant female)

18
Q

Transgenerational

Between or across generations? Is the germ line directly exposed?

Generational Inheritance

A

Across two multiple generations
Germ line not directly exposed

Neurogenetics (25 decks)

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