Lecture 4- Intercellular signalling I: How cells communicate in animals Flashcards
1
Q
examples of long-distance proteins
A
hedgehog, Wnt, TGFbeta
2
Q
membrane proteins examples
A
notch, ephrin
3
Q
example of a small metabolite which can penetrate membranes
A
retinoic acid
3
Q
what TF does Notch work on
A
Csl
4
Q
what genes does Notch induce expression of
A
hairy/Hes
5
Q
what does ephrin do
A
involved in cell migration, causes attraction or repulsion- so involved in migration of cell types like melanocytes and neural crest
6
Q
Wnt canonical receptors
A
frizzled, LRP
7
Q
Wnt intermediates
A
Dishevelled, B-catenin
8
Q
Hh effector
A
Gli- long-form for activation, short-form for repression
9
Q
RA dimer
A
RAR/RXR, activates gene expression
10
Q
example enzyme which helps block RA dimer formation
A
CRABP
11
Q
example of combinatorial activity
A
Shh, Fgf, Wnt all in limb patterning along different axes
