Lecture 5 Flashcards
(50 cards)
What parts of the brain are first degenerated in HD
Caudate and putamen
Can HD affect other areas of the brain besides CP
Yes as it progresses
Is HD hypo or hyper kinetic
Hyper
Juvenile onset age HD
before 20
Juvenile onset prevalence HD
10%
When do most people develop motor symptoms of HD
In their 40s or 50s
What percent of people have motor symptoms of HD after age 60
10%
Adult onset age of HD
After age 20
Major stages of adult onset HD progression
- Prodrome
2. Manifest
Prodrome
Presymptomatic stage. Often includes a host of subtle yet detectable symptoms occurring up to 15 years before HD diagnosis
Manifest
Stages of disease progression follow a clinical diagnosis
Substages of manifest
- Early stage
- Middle stage
- Late stage
Length of survival after clinical diagnosis of HD
10-20 years
Why is HD considered a 3 disorder disease
Has 3 major disorders involved (movement, cognitive, and psychiatric)
Involuntary movements
Chorea
When does chorea typically increase in HD
Middle stages
When does chorea decline in HD
As rigidity increases in the later stages
What movements are imapired in HD
Voluntary
Other movement issues in HD
Reduced manual dexterity, slurred speech, swallowing difficulties, problems with balance, and falls
Exectutive efficacy in HD
Reduction of speed amd flexibility in mental processing
What cognitive skills decline in HD
Learning, memory, and language
Perception issues in HD
Trouble with perception of emotion, time, and space
What is the first sense to be lost in neurological diseases
Smell
Are HD patients aware of their actions and feelings
No
