Lecture 5

Question 1

Synaptic Transmission?

Answer 1

Interpreting the transmitted signal and translation of the signal into a change in postsynaptic Vm

Question 2

Classes of Membrane Receptors?

Answer 2

1) Ionotropic (Ligand-Gated)
2) Metabotropic (GPCR)

Question 3

Ionotropic?

Answer 3

(Ligand-Gated)
Fast Response

Question 4

Metabotropic?

Answer 4

(GPCR)
Slow and variable response

Question 5

Ionotropic (Ligand-Gated) Receptors?

Answer 5

Direct activation of the neurotransmitter receptor channel elicits fast PSPs

Question 6

Ionotropic (Ligand-Gated) Receptors Examples?

Answer 6

1) nAChR Receptor- Acetylcholine
2) NMDA and AMPA (Kainate) Receptors- Glutamate
3) Serotonin Receptors- 5-HT3 (Excitatory)
4) GABA Receptors(Types A and C)
5) Glycine Receptor (GlyR)

Question 7

Metabotropic (G-Protein Coupled) Receptors?

Answer 7

Activation of G-Protein coupled receptor elicits slow PSPs

Question 8

Metabotropic (G-Protein Coupled) Receptors Examples?

Answer 8

1) Muscarinic Acetylcholine Receptor (mAChR)
2) Metabotropic Glutamate Receptor (mGluR)
3) Biogenic Amine Receptors (Serotonin, Dopamine, NE, Histamine)
4) GABA Receptor (Type B)

Question 9

Excitatory Postsynaptic Potentials (EPSP)?

Answer 9

Postsynaptic potentials that increase the probability of causing the postsynaptic cell to fire an AP

Question 10

Inhibitory Postsynaptic Potentials (IPSP)?

Answer 10

Postsynaptic potentials that decrease the probability of causing the postsynaptic cell to fire an AP

Question 11

Following neurotransmitter receptor activation, the postsynaptic membrane potential (Vm) will always move?

Answer 11

Toward the reversal potential of the activated neurotransmitter receptor induced conductance

Question 12

Reversal Potential?

Answer 12

Point at which direction of net current flow reverses and is the same as the Equilibrium Potential

Question 13

EPSP?

Answer 13

Reversal potential of induced conductance is more positive than threshold

Question 14

IPSP?

Answer 14

Reversal potential of induced conductance is more negative than threshold

Question 15

Na+ = ?

Answer 15

EPSP

Question 16

K+ = ?

Answer 16

IPSP

Question 17

Ca+ = ?

Answer 17

EPSP

Question 18

Cl- = ?

Answer 18

IPSP

Question 19

Na+/K+ equally = ?

Answer 19

EPSP

Question 20

Decreasing conductance of K+ produces?

Answer 20

EPSP

Question 21

Convergence of input?

Answer 21

Several neurons synapse onto a single neuron

Question 22

Divergence of output?

Answer 22

A single neuron projects onto several neurons

Question 23

Grand Postsynaptic Potential?

Answer 23

Temporal and Spatial Summation of all EPSPs and IPSPs determines excitability of the postsynaptic cell

Question 24

Afferent Neurons?

Answer 24

Carry information from sensory receptors to the CNS (ex. Brain and Spinal Cord)

Question 25

Efferent Neurons?

Answer 25

Carry motor information away from the CNS to the muscles and glands of the body