Lecture 5 Flashcards

1
Q

true or false the bigger the group is the more there are individual differences in pain

A

true

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2
Q

true or false: when you get a disease or like a surgery do you have high chances of have chronic pain susceptibility

A

true

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3
Q

what is the % of chronic post surgical pain

A

7%

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4
Q

what are the two main reasons for interindividual variability

A

-organismic
-environmental

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5
Q

what are organismic differences?

A

–genetic backround
-sex
-psychological traits: stable
-age
-circadian rythyms

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6
Q

what are enviromental differences

A

-past experiences
-gender
-psychological states: unstable
-diet
-legal factors
-social factors

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7
Q

true or false the biological model of pain is true

A

nah it is false

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8
Q

what is the biological model

A

it is the model that says oh if your bladder hurts, then your problem is the bladder

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9
Q

what is a study that you can do to see if pain genes are important heritable

A

-if identical twins not =fraternal twins then the genes are not important
-if identical twins==fraternal genes for pain means environment factors for pain

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10
Q

what is the % of pain genes that are heritable

A

40%

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11
Q

true or false: mices have the same % of pain genes that are heritable

A

true

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12
Q

what is an example of a monogenic pain disorder

A

HSAN aka pain insensitivity

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13
Q

true or false: most pain diseases are omnigenic

A

true

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14
Q

what is the gene that get the most attention for pain genetics

A

COMT

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15
Q

what is the study to study temporomandibular disorder aka TMD

A

the study they took a bunch of people and they knew which % will have TMD and they did a bunch of tests
-PILL and scl 90r somatization were the best tests to know
-both measure somatization which is the perseverating about bodily sensations =2X chances

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16
Q

true or false: osteoarthritis in woman is more before 45

A

false it is in means, woman is after

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17
Q

why do woman have more chronic pain

A

-more susceptible to some disease
-doctors treat them differently
-men go to the doctors less

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18
Q

are there sex differences

A

true

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19
Q

true or false woman said they had more pain when they were tested with men

A

true and men they say they have less pain with women

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20
Q

monocycline blocks what?

A

microglia

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21
Q

monocycline has an effect on women

A

FALSE it does not, but men yes

22
Q

could hormones affect sex differences

A

yeah

23
Q

when does chronic pain peaks

A

in middle age

24
Q

which race is more susceptible to pain

A

black people

25
Q

when is osteoarthritis of the kee more peaking

A

during the evening

26
Q

what are the significative factors in chronic pain

A

-if u have a job
-physical work
-body mass
-marital status

27
Q

what is the best thing to do when someone is hurt af

A

distract them

28
Q

what happens to you brain when you see someone in pain

A

the same brain parts activate aka same when u are in pain

29
Q

which type of food can help u reduce the pain when you eat if before

A

soyyyy 6%

30
Q

who discovered placebo and how

A

henry beecher in ww2 he lied to soldiers said he would give them opiates

31
Q

when does placebo works

A

in painnnn

32
Q

what is the placebo effect?

A

-CONDITIONING
-EXPECTATION
-DESIRE

33
Q

what are the 2 things you can do to study when there is placebo

A

-you either say there is no active treatment but you know there will be a treatment
-or you know you get a treatment but you dunno what

34
Q

what is no expectancy

A

you think you don’t get a treatment but you do

35
Q

what is positive expectancy

A

you know you will get it

36
Q

what is negative expectancy

A

you think the meds will stop but it did not

37
Q

what is the % of people that placebo affects

A

30%

38
Q

what can affect placebo

A

-subjectivity of measure
-nature of verbal suggestions
-previous experience
-desire of patient and clinician
-bedside manner/deep voices/white coats
-physical properties of placebo itself
-personality variab;es

39
Q

what can block placebo opiod

A

naloxone

40
Q

true or false morphine produces analgesic that is not dependant on cb1 receptor

A

true

41
Q

what does katolarac and rimonbarant do

A

also produce analgesia that is not dependant on cb1 but its placebo is cb1 dependant

42
Q

what is nocebo

A

negative placebo

43
Q

cck does what?

A

responsible for getting smaller placebo

44
Q

what does proglumide do

A

blocks cck=more placeboooo

45
Q

true or false: sometimes placebo works better than meds

A

true

46
Q

true or false placebo effect just gets better

A

true

47
Q

true or false drug response just gets smaller

A

false it stays the same

48
Q

true or false: treatment advantage stays the same

A

false; it gets smaller

49
Q

true or false; placebo gets gigger irl than in trials

A

true

50
Q

why would placebo be big ouside of meds

A

they go out
you think it will work