Lecture 5 Part 1

Question 1

is hepatitis A acute or chronic

Answer 1

acute

Question 2

is hepatits B acute or chronic

Answer 2

can be either, but is acute most of the time

Question 3

is hepatits C acute or chronic

Answer 3

chronic

Question 4

is hepatitis E acute or chronic

Answer 4

usually acute. very rarely becomes chronic

Question 5

true or false

most hepatitis viruses have a specific tropism for the liver

Answer 5

FALSE – all do

Question 6

true or false

ALL hepatitis viruses replicate in hepatocytes

Answer 6

true

Question 7

true or false

each hepatitis virus comes from a distinct individual family of viruses

Answer 7

true

Question 8

name the virus for HAV (hepatitis A)

Answer 8

picornavirus (RNA+)

Question 9

name the virus for HBV (hepatitis B)

Answer 9

hepadnavirus (dsDNA)

Question 10

name the virus for HCV (hepatitis C)

Answer 10

flavivirus (RNA+)

Question 11

name the virus for HDV (hepatitis D)

Answer 11

delta virus (RNA-)

Question 12

name the virus for HEV (hepatitis E)

Answer 12

calicivirus (RNA+)

Question 13

what are the most common hepatitis viruses

Answer 13

A,B,C

Question 14

For which hepatitis viruses is there a vaccine?

Answer 14

hepatitis A, B, and D

Question 15

which hepatitis viruses are transmitted primarily through the fecal oral route

Answer 15

A and E

Question 16

which hepatitis viruses are most commonly transmitted via the parenteral route

Answer 16

B and C

Question 17

can hepatitis D result in a chronic infection?

Answer 17

yes
50-70% of the time

Question 18

which hepatitis virus is a major cause of infectious hepatitis

Answer 18

hepatitis A

Question 19

HAV reaches the liver via…..

Answer 19

hepatic portal system

Question 20

is hepatitis A oncogenic

Answer 20

no

Question 21

HAV is cleared by what cells

Answer 21

NK cells, cd8 t cells, antibodies

Question 22

name 4 symptoms of hepatitis A

Answer 22

fever anorexia jaundice nausea

Question 23

explain the movement of HAV

Answer 23

slowly replicates in hepatocytes
shed into bile to small intestive via the bile duct
shed in the stool 10 days before symptoms occur

Question 24

HAV is transmitted via the ____ but infects the ____. what can you conclude from this?

Answer 24

transmitted via the oral fecal route (picornavirus) yet infects the liver. therefore, it travels through viremia – gets to liver through hepatic portal system

Question 25

what goes up to signal hepatic cell injury, and thus viral infection? (hepatitis)

Answer 25

alanine aminotransferase

Question 26

true or false hepatitis A can be seen in the feces before it ever gets to the liver

Answer 26

true

Question 27

which virus makes DECOYS? what do these decoys consist of?

Answer 27

hepatitis B consists of the dane particle with hepatitis B surface antigen (HBsAg) ONLY with no nucleic acid inside

Question 28

how is hepatitis B virus unique in what it contains?

Answer 28

it’s a DNA virus that contains reverse transcriptase. replicates itself through an RNA intermediate

Question 29

do humans encode a reverse transcriptase?

Answer 29

no

Question 30

how is hepatitis B transmitted?

Answer 30

in bodily fluids

Question 31

does HBV often result in chronic infection?

Answer 31

NO — sometimes

Question 32

true or false hepatitis B can be symptomatic or asymptomatic

Answer 32

true

Question 33

what is the name of the hepatitis B surface antigen

Answer 33

HBsAg

Question 34

what is the name of the hepatitis B CORE antigen? what does it do?

Answer 34

HBcAg forms the ICOSAHEDRAL CAPSID for hepatitis B

Question 35

WHY does HBV give minimal cytopathix damage?

Answer 35

it slowly replicates in the hepatocytes

Question 36

what is HBeAg used as?

Answer 36

not really clear — used as a marker

Question 37

what are the antibodies produced in response to HBsAg HBcAg HbeAg

Answer 37

anti-Hbs anti-Hbc anti-Hbe

Question 38

what is the name for the hepatitis b surface antigen and what does it consist of

Answer 38

HBsAg 3 polypeptides—- L M S

Question 39

true or false HBV does NOT contain protein kinase

Answer 39

FALSE — it does

Question 40

dane particle consists of…

Answer 40

S plus some M antigen

Question 41

explain the structure of DNA in HBV

Answer 41

double strand with a gap

Question 42

when a new HBV virus is released from a cell, what comes with it?

Answer 42

HBsAg is released with the decoys HBeAg is also released (glycoprotein marker)

Question 43

what enzyme destroys the RNA in an RNA DNA hybrid when making new HBV?

Answer 43

rnase H

Question 44

chronic, active HBV infection eventually reaches…

Answer 44

a plateau