lecture 6

Question 1

the ligand-binding domain is responsible for the:

Answer 1

translocation

Question 2

Glucocorticoid receptor (GR) translocates to the ___ in the presence of hormone

Answer 2

Nucleus

Question 3

eukaryotic activators/ repressors usually bind directly to DNA in

Answer 3

promotors of enhancers

Question 4

activators/repressors affect gene expression by recruiting multi-subunit ______ that modulate chromatin structure or interact with the mediator and the GTF

Answer 4

co-activator/co-repressor complexes

Question 5

_____ stimulate the assembly of pre-initiation complexes that move nucleosomes away from the promoters

Answer 5

Activators

Question 6

_____ most frequently work through the build up of repressive chromatic structures

Answer 6

repressors

Question 7

establish and maintain open chromatin structure - do not directly activate transcription

Answer 7

Pioneer transcriptio factor

Question 8

nucleosomes is built of 8 histones

Answer 8

H2A, H2B, H3, H4

Question 9

Histone N-termini are not structured and protrude away from the histone core. These N-termini are modified by:

Answer 9

Post translational modifications (PTMs)

Question 10

PTMs dictate the ______ wrapped around the nucleosome

Answer 10

function of the DNA