lecture 7

Question 1

positions in the genomes where large heterochromatin blocks are established and maintained are called:

Answer 1

Silencers

Question 2

genes that are ______ to silencers are strongly _____

Answer 2

close
repressed

Question 3

3 functions of chromatin remodelling factors

Answer 3

• move nucleosomes along the DNA by Sliding or transferring them
• shift nucleosomes away from the promoter/enhancer sites and gives transcription factors access to the DNA
• chromatin-remodeling factors use ATP to move nucleosomes

Question 4

the mediator directly interacts with _____ and ____

Answer 4

transcriptional activators and GTFS

Question 5

epigenetic memory of transcription
how do cells remember which genes to express

Answer 5

reconstitution of the same chromatin structure after the passage of the replication fork

Question 6

DNA methylation is alwasy associated woth _____ and ______

Answer 6

heterochromatin and repressed genes

Question 7

histone acetylation is almost always associated with ___ and ____

Answer 7

active genes and euchromatin

Question 8

histone deacetlylation is almost always associated with _____ and _____

Answer 8

gene repression and heterochromatin

Question 9

histone methylation is associated with both _____ and ___

Answer 9

gene activation and repression