Lecture 6 Flashcards
What are 2 important hormones in stimulating gonads
- Follicle-stimulating hormone
2. Luteinizing hormone
What is the pituitary gland under the control of
CNS control, particularly hypothalamus
What neurons does the hypothalamus contain specific for reproductive functions (4)
- Paraventricular
- Supraoptic
- Media preoptic
- Arcuate nuclei
What sort of connection does the hypothalamus have with the pituitary
Neural and hormonal
What does the hypothalamus secrete to control reproduction (2)
- Oxytocin
2. Gonadotrophin releasing hormone (GnRH)
How is GnRH released
in pulsatile pattern
What does the release of GnRH stimulate
the release of LH and FSH from different gonadotroph cells in anterior cells
After what 2 events is there an increase in FSH and LH
- Ovariectomy
2. Menopause
How is the positive feedback by osterogens characterised
Surge of GnRH, LH and FSH
How is the negative feedback of ovarian hormones regulated
Absence of oestradiol which normally surpasses tonic GnRH secretion
What is the effect of progesterone
Enhances negative feedback of oestradiol during luteal phase and blocks positive feedback oestradiol
What is the effect of inhibits A and B
Selectively block FSH secretion
What does oestradiol suppress
tonic GnRH secretions -> negative feedback
What occurs if there is a rapid increase of oestradiol
LH and FSH secretion enhanced not suppressed and it is due to the activation of the hypothalamic surge centre
