lecture 6 GI

Question 1

.5m^2 to 300m^2

Answer 1

after infoldings(fold of kerckring, villi, and microvilli)

Question 2

exists in villi and microvilli transporters for absorbing enzymes to break down protein and carb 1 nd 2

Answer 2

1 and 2

Question 3

tf cells in small intestine are most mature when at the crypts

Answer 3

F when at the microvilli

Question 4

Label the channel and pump

Answer 4

channel on luminalside (requires Na to go downstream)

pump on basolateral

Question 5

pump

gets Na secreted

doesnt require energy

gets Na absorbed

Na ends up in the lumen

Answer 5

gets Na absorbed

on interstitium and cap side

Question 6

which of the following can pass paracellularly

ions

Water

Glucose

Nas

1 and 2

Answer 6

ions and water

1 and 2

Question 7

TF tight junction are tight at proximal duodenum

Answer 7

F they are loosest at duodenum

Question 8

Correct the statement

Tight Junction Form boundary between apical and basolateral domains of plasma membrane maintaining symmetrical distribution of membrane proteins

Answer 8

Tight Junction Form boundary between apical and basolateral domains of plasma membrane maintaining asymmetrical distribution of membrane proteins

Question 9

what is absorbed after Na paracellularly?

Answer 9

Question 10

Na H20 follow —-?

Answer 10

Question 11

made of only alpha 1,4 glucose links?

amylose

cellulose

amylopectin

Answer 11

amylose

Question 12

made of glucose beta 1,4 links

amylopectin

amylose

cellulose

sucrose

Answer 12

cellulose

Question 13

tf cellulose cant be broken into single glucose mol.

Answer 13

T

Question 14

made up of glucose alpha1,2 fructose bonds

sucrose

lactose

maltose

Answer 14

sucrose

Question 15

made of glucose beta 1,4 galactose mol

sucrose

lactose

maltose

Answer 15

lactose

Question 16

tf maltose makes up the least percentage of carbs and contains 2 glucose as it constituents

Answer 16

T

glu alpha 1,4 glu

Question 17

where does alpha amylase cut?

Answer 17

internal glu alpha 1,4 glu

Question 18

tf sucrase can break down maltase and maltriose

Answer 18

T

Question 19

alpha dextrin is broken down into

glucose

galactose

fructose

Answer 19

Glucose

Question 20

which of the following cant break down maltose and maltriose

lactase

sucrase

maltase

alpha dextrinase

Answer 20

lactase

Question 21

digestion and absorption of monosach. happens

in the

1/3 of Si

2/3 of SI

3/3 of SI

Answer 21

1/3 of SI

Question 22

SGLT1

na glucose/ galactose contrasport(only binds one)

na glucose/ galactose contrasport(only binds both)

na glucose/ fructose contrasport(only binds one)

na glucose/ fructose contrasport(binds both)

Answer 22

na glucose/ galactose contrasport(only binds one)

Question 23

GLUT 5

transports Fructose into intestinal cell

transports fructose and glucose to blood

requires Na

is next to glut 2

Answer 23

transports Fructose into intestinal cell

Question 24

Tf glut transport glucose, fructose, galactose into blood with Na

Answer 24

F

no Na

Question 25

tf glut 5 is energized and carries fructose into the cell

Answer 25

f its a facilitated carrier and does carry fructose into cell

Question 26

tf all proteins hve to be broken down into single aa to be transported

Answer 26

F they can be di and tri peptides

Question 27

tf peptidases are active in breaking down proteins(\> 3 aa) to only single AA

Answer 27

F it breaks down proteins(\>3aa) to tri, di, single aa

Question 28

Answer 28

1--\>transfer di and tri peptide into cell. cytolosolic peptidase digest them to single aa once in cel 2single aa goes with Na into cell(using nrg of NA) 3 facilitated carrier of AA

Question 29

TF on the Basolaateral membrane the aa only gets to the cap side by facilitate transport

Answer 29

F it can diffuse thru lipid bilayer

Question 30

TF most water absorption comes from Smal intestine

Answer 30

T

Question 31

which of the following does not absorb water by isoosmotic absorption prox duodenum jejunam colon ileum

Answer 31

prox duodenum

Question 32

the proxima duodenum absorbs water thru

Answer 32

osmotic equilibration

Question 33

tf absorption water is primary to absorption of solute

Answer 33

F it is secondary

Question 34

tf most of the Na pumps are on the lateral side close to junction

Answer 34

T

Question 35

Order it then goes into interstitial space Na goes downhill into cell. pressure build up in interstitial space attracts h20 and fluid travels to cap

Answer 35

Na goes downhill into cell. and goes into interstitial space attracts h20 pressure build up in interstitial space and fluid travels to cap

Question 36

tf the fluid absorbed in the small intestine cells is isotonic to plasma

Answer 36

T there isnt a huge requirement for increase in osmolarity for H20 to follor salt into interstitial space

Question 37

TF small intestine proximal side has a large diff in voltage

Answer 37

f small diff because leaky junctions and transfer of NA

Question 38

tf during a meal CL is absorbed

Answer 38

F it is secreted

Question 39

How does cholera affect Cl transport camp is irreversibly act Aden cyclase is irreversibly act Dec Cl secreted

Answer 39

camp is irreversibly act NT binds receptor and inc Camp thru aden cyclase. since it is irreversible it act a kinase to phos the CL channel. Cl leaves and Na and H20 subsequently follow. this happens in excess

Question 40

Tf Ca is absorbed in the Small intestine

Answer 40

T

Question 41

paracellular transport of ca in SI is active passive happens at the duodenum happens under low ca intake

Answer 41

passive need adequate to high Ca intake and happens at ileum

Question 42

Ca transport transceullulary calbindin,channel, pump pump channel, calbindin channel , calbindin, pump

Answer 42

channel , calbindin, pump

Question 43

tf the pump and calbindin are activated by vit d in the transcellular transport of Ca

Answer 43

T

Question 44

DMT1

Answer 44

proton dependent Fe import

Question 45

Ferratin

Answer 45

stores Fe and is irreeversible

Question 46

mobiferrin

Answer 46

form complex with fe

Question 47

ferroportin

Answer 47

basolt. side

Question 48

tf after Fe is transferred to blood it is transferred to transferrin(plasma protein)

Answer 48

t

Question 49

Ferratin inh by low body fe when inh allows less absorbtion inh by more body fe when inh allows more absorption more than 1 name which

Answer 49

1 and 4

Question 50

hepcidin

Answer 50

degrades ferropotin and limits Fe absorption

Question 51

which of the following doesnt supress hepcidin anemia hypoxia erythropoeises iron loading

Answer 51

iron loading increase hepicidin

Question 52

hypoxia increases hepcidin increases HIF and transporters decreases HIF and transporters

Answer 52

increases HIF and transporters

Question 53

low iron levels

Answer 53

inc hif and transporters

Question 54

high O2 and Fe cell levels

Answer 54

dec. HIF and transporters

Question 55

hereditary chromatosis

Answer 55

deficiency in hepcidin