Lecture 6 Reading Flashcards Preview

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Flashcards in Lecture 6 Reading Deck (10):

DNA polymerase

The first nucleotide polymerizing enzyme


3'-to-5' proofreading exonuclease

Clips odd any unpaired or mispaired residues at the primer terminus, continuing until enough nucleotides have been removed to regenerate a correctly base paired 3'-OH terminus that can prime DNA synthesis


DNA primase

Uses ribonucleoside triphosphate to synthesize short RNA primers on the lagging strand


What two replication proteins are needed to open double helix

DNA helicase and single-strand DNA binding proteins


Single strand DNA bind proteins

Stabilize unwound conformation of DNA


Sliding clamp

Keeps polymerase firmly on the DNA when it is moving, but releases it as soon as the polymerase runs into a double strand region of the DNA


Clamp loader

Special protein complex that Hydrolyzes ATP as loads the clamp on to a primer-template junction


Initiator proteins

Begin process of DNA replication by binding to double strand DNA and prying the two strands apart, breaking h bonds bet, bases


Replication origins

Position at which dna helix is first opened


DNA templating

Mechanism cell uses to copy nucleotide sequence of one DNA strand into a complementary DNA sequence.