Lecture 6 Reading Flashcards Preview

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Flashcards in Lecture 6 Reading Deck (10):
1

DNA polymerase

The first nucleotide polymerizing enzyme

2

3'-to-5' proofreading exonuclease

Clips odd any unpaired or mispaired residues at the primer terminus, continuing until enough nucleotides have been removed to regenerate a correctly base paired 3'-OH terminus that can prime DNA synthesis

3

DNA primase

Uses ribonucleoside triphosphate to synthesize short RNA primers on the lagging strand

4

What two replication proteins are needed to open double helix

DNA helicase and single-strand DNA binding proteins

5

Single strand DNA bind proteins

Stabilize unwound conformation of DNA

6

Sliding clamp

Keeps polymerase firmly on the DNA when it is moving, but releases it as soon as the polymerase runs into a double strand region of the DNA

7

Clamp loader

Special protein complex that Hydrolyzes ATP as loads the clamp on to a primer-template junction

8

Initiator proteins

Begin process of DNA replication by binding to double strand DNA and prying the two strands apart, breaking h bonds bet, bases

9

Replication origins

Position at which dna helix is first opened

10

DNA templating

Mechanism cell uses to copy nucleotide sequence of one DNA strand into a complementary DNA sequence.