lecture 7

Question 1

The normal immune system is…

Answer 1

tolerant to self-antigens

Question 2

where is central tolerance induced?

Answer 2

in primar lymphoid organs (thymus, bone marrow) during lymphocyte maturation

Question 3

mechanisms of central tolerance are

Answer 3

elimination of self-reactive T and B lymphocytes, receptor editing ( B lymphocytes)

Question 4

peripheral tolerance is induced

Answer 4

when mature lymphocytes recognize self antigens in peripheral tissues under particular conditions

Question 5

mechanisms of peripheral tolerance are:

Answer 5

anergy, suppression (Tregs) and deletion

Question 6

What induces anergy?

Answer 6

induced in CD4+ T cells in absence of co-stimulation

Question 7

anergy is a interaction between

Answer 7

B7 with inhibitory CTLA-4

Question 8

autoimmunity and autoinflammation is

Answer 8

a failure of self-tolerance

Question 9

autoimmunity is

Answer 9

an imbalance between lymphocyte activation and control

Question 10

autoimmunity mechanisms are

Answer 10

genetic (MHC) and environmental (infections)

Question 11

impact of infections in autoimmunity

Answer 11

expression of co-stimulators and molecular mimicry

Question 12

autoimmune diseases can be

Answer 12

systemic or organ specific

Question 13

mechanisms of autoimmune tissue injury

Answer 13

immune complexes, circulating autoantibodies and auto reactive T lymphocytes