Lecture 7 The first steps in vision: From light to neural signals Flashcards

1
Q

Steps 1-3 of how the eye works

A
  1. Light passes through the cornea, some of this light enters the eye through the pupil
  2. Then through the aqueous humor (nourishment)
  3. Next the lens to focus the image on the retina
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2
Q

Steps 4-7 of how the eye works

A
  1. Vitreous humour,
  2. Retina, light is converted into electrical signals
  3. Fovea,
  4. Optic disc, information transmitted onwards to the brain
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3
Q

Key info about the fovea

A

maximum resolution focus, responsible for high acuity vision it is densely saturated with cone receptors to help us see fine detail.

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4
Q

Emmetropia

A
  • Normal vision
    Light rays hit at the back of the eye with no blur
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5
Q

Myopia

A

Short sighted
if the eyeball is too long or the cornea is too curved
raised light converge before they hit the retina so the image appears blurry

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6
Q

how glasses correct myopia

A

diverges light rays entering the eye so they focus a little further back. landing directly on the retina instead of infront of it.

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7
Q

Hyperopia

A

long sighted
can’t see objects close as light converges too far back of the eye

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8
Q

Accomodation

A

the eyes ability to adjust focus to see objects clearly at different distances

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9
Q

Key facts about accomodation

A

Happens in a quarter of a second
15 dioptre accommodation range at birth

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10
Q

How eyes accommodate to see near objects

A

lens becomes thicker, this allows the light rays to refract more strongly

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11
Q

How eyes accommodate to see objects far away

A

lens is pulled thin, allowing the light rays to refract slightly

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12
Q

How the ability to accomodate is affected by age

A

Presbyopia - ability declines with age
1D drop every five years until 30
Less than 2.5D range by age 40-50 yrs

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13
Q

Astigmatism definition

A

Blur due to irregular curvature of cornea
Image not focusing on the eye due to lens or the shape of the cornea

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14
Q

Retina: vertical connections

A

photoreceptors
bipolar cells
ganglion cells

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15
Q

Retina: Horizontal connections

A

Horizontal cells
Amacrine cells

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16
Q

Role of photoceptor’s

A

converts light into electrical signals that the brain interprets as sight

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17
Q

Key facts about cones

A

See in colours and fine details in light
densely packed in the fovea

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18
Q

Key facts about rods

A

responsible for vision in low light
no rods in the fovea
responsible for our peripheral vision

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19
Q

Three cone types

A

Short, medium, long
No S cones at the fovea

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20
Q

Difference between photoreceptor peaks at different wavelengths

A

Rod sensitivity peaks at a lower wavelength than cone sensitivity (20 deg)

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21
Q

What is the blind spot

A

Where the optic nerve connects to the retina, lacks photoreceptors

22
Q

Rods maximum density

A

between 0-10 mm on either side of the fovea

23
Q

Fundus definition

A

interior lining of the eye, including retina, vascular tree, macula, fovea, optic disc

24
Q

Bipolar cells: Midget

A

Fovea, cones, low convergence (1:1), good resolution

25
Bipolar cells: diffuse
periphery, rods + cones, high convergence (many: 1) good sensitivity
26
Bipolar cells: ON
Depolarize when light increases
27
depolarize definition
membrane potential more positive
28
Bipolar cells: OFF
hyperpolarize when light increases
29
hyperpolarize definition
membrane potential becomes more negative
30
Low convergence definition
1:1 connection, a single cone connects to a single bipolar cells, high resolution, low sensitivity
31
High convergence definition
Mnay:1 connection; many rods connect to a single bipolar cell Low acuity high sensitivity
32
Ganglion P cells
70% midget bipolar, parvocellular pathway, small dendritic fields and receptive fields
33
Ganglion cells M cells
10% diffuse bipolar, magnocellular pathway Large dendritic fields and receptive fields
34
Light transduction definition
The pattern of light falling on the retina is encoded as graded potentials and spikes
35
Photoreceptors: Outer segment
photopigment molecules stored near pigment epithelium
36
Photoreceptors: Inner segment
photopigment molecules made Pigment = protein + chromophore G-protein coupled receptors
37
Photoreceptors: synaptic terminal
signal sent onward to the next (bipolar)
38
Light transduction at the photoreceptor steps 1-4
1. Photon captured by chromophore in outer segment 2. Photon energy transferred to chromophore (photoactivation) 3. Chromophore changes configuration (isomerization) 11-cis-retinal to all-trans-retinal, breaks free of opsin 4. Hyperpolarization: membrane channels close, Na+ reduced, cell becomes negatively charged
39
Light transduction at the photoreceptor steps 5-7
5. Calcium channels close, calcium decreases, glutamate decreases 6. Reduction in glutamate is a signal to bipolar cell that the rd/cone has captured a photon the signal cascades through to ganglion cells and onwards to the brain through the optic nerve 7. Photopigment is regenerated
40
Receptive field
the region in visual space to which a neuron responds
41
ON-center OFF-surround receptive fields
cell response increases when light falls on its center, decreases when light falls on its surround
42
OFF-center ON-surround receptive fields
Cell response decreases when light falls on its center, increased when light falls on it's surround
43
Effect of spot size on ON-center cell response
cell responds most when spot size is perfectly matched to the center Lateral inhibition: reduction in cell firing rate due to stimulation outside the center of the receptive field enabled by horizontal cells
44
Lateral inhibition in ganglion cells
Antagonistic neural interaction between adjacent retinal cells Produces center-surround organization of ganglion cell receptive fields Acts as a filter Signals information about change in illumination across a scene Enhances the edges in a present scene
45
Lateral inhibition in ganglion cells: filter
Large response for differences in light intensity between center and surround small response for average or ambient illumination
46
Edge enhancement by ganglion cell responses: center-surround receptive fields
emphasizes edges
47
What an ON-center OFF-surround cell wants
darkness in the surround part of the receptive field
48
Hermann grid classical explanation 1.
Grey sports seen at crossings and not streets The cell on the street has more darkness in it's surround at the crossing has less darkness in it's surround
49
Hermann grid classical explanation ON-centre receptive fields
fires more when dark in surround and less when light in surround therefore, fires less at crossings and more on the streets so grey spots seen at crossings
50
Hermann gris grey sports seen in periphery and not fovea
receptive fields large in periphery, cover both light and dark regions receptive fields small in fovea, fit within the crossing, no differential response