Lecture 8 - Immunity and Diseases of Immune Origin

Question 1

Type I Hypersensitivity

Answer 1

Immediate
Recipe: Antigen, IgE, Mast cells
Hay fever, asthma, hives, anaphylaxis

Question 2

Type II Hypersensitivity

Answer 2

Antibody Mediated
Erythrocytes, platelets
Ach Receptor
Blood Tranfusions - ABO mismatch = hemolysis

Question 3

Type III Hypersensitivity

Answer 3

Immune Complex Disease
Glomerulonephritis
“Butterfly Rash”

Question 4

Type IV Hypersensitivity

Answer 4

Cell-mediated
TB (PPD converter used to test)
Contact Dermatitis OR Mucositis

Question 5

What is a pannus

Answer 5

Hyperplastic synovium in RA patients that erodes cartilage and leads to joint destruction

Question 6

What two Ab in Rheumatoid Arthritis

Answer 6

IgM autoantibody to Fc portion of IgG

Question 7

List of autoimmune diseases

Answer 7

__Rheumatoid Arthritis - Pannus destorys cartilage
__Scleroderma - Mask like skin due to fibrosis of skin in females (LOCALIZED)
- affects salivary glands –> oral complications
___CREST Syndrome - LIMITED FORM
Calcinosis - calcium in skin
Raynaud Phenom - response to cold (blue fingers)
Esophageal dysfunction - acid reflux
Sclerodactly - tight skin
Telangiectasia - dilation of capillaries = red lesions on skin
___Hidebound Disease (Archaic)
___Sjogren Syndrome

Question 8

Definition of morphea:

Answer 8

mild, localized disease

Question 9

What is the Sicca Complex?

Answer 9

Xerostomia and Xeropthalmia