Lecture 88+89 - Antivirals

Question 1

aMANTAdine may inhibit _____ ion channel, which block accumulation of H+ in the infected cell that would otherwise trigger uncoating. Remember uncoating is pH dependent.

Answer 1

M2 ion channel

Question 2

______ (tamiflu - remember Tami V. from the sketchy vid) is the go-to treatment and is NOT age-restricted. Keep in mind this inhibits viral ________, which normally cleaves sialic acid to release new virions.

Answer 2

Oseltamivir

Baloxavir

Neuraminidase

Question 3

_______ is an antiviral for influenza (different mech of action from Tami V, and it is given to children 12 years or older.

Answer 3

Baloxavir

Question 4

_______ is used to treat CMV because CMV does not have a thymidine kindase, which adds the first phosphorylation to Acyclovir.

Answer 4

Ganciclovir

Question 5

_______ is an antiviral used to treat ALL genotypes of Hep C and is ______ bioavailable.

Answer 5

Sofosbuvir

Orally