lecture 9 - lung function and disease Flashcards

1
Q

what do the conducting airways do

A

carry air to lungs where gas exchange of O2 and CO2 occurs

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2
Q

what does the right side of the heart pump

A

deoxygenated blood

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3
Q

what is pulmonary circulation

A

Deoxygenated blood from veins -> lungs

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4
Q

what does pulmonary circulation allow

A

gas exchange

Reoxygenated blood -> left side of heart -> body

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5
Q

why is circulation important

A

Simple diffusion of O2 and CO2 is sufficient for metabolism in single cell organisms.

Small multicellular organisms circumvent this with thin walls and tubular structures.

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6
Q

what is the primary purpose of respiratory system

A

gas exchange - submission of O2 and removal of CO2 from tissues

regulation of acid-base status by con trolling co2

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7
Q

what are the disadvantages of respiratory system

A

easy access for micropathogens, dust

warm moist environment in lungs

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8
Q

how is o2 carried

A

by being bound to Hb

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9
Q

how many o2s bind to hb

A

4

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10
Q

is o2 soluble or insoluble in water

A

insoluble

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11
Q

what does blood o2 content depend on

A

PO2

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12
Q

why is the o2 dissociation curve steep

A

due to the cooperative nature of O2 binding, facilitating the delivery of O2 to the tissues as the PO2 falls.

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13
Q

what is o2 delivery facilitated by?

A

increased PCO2, temperature and low acid

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14
Q

how do things facilitate o2 delivery

A

reduces the affinity of Hb to O2 -> shifting the curve to the right

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15
Q

what does water and CO2 form

A

weak carbonic acid

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16
Q

what does carbonic acid dissociate to

A

HCO3- and H+

17
Q

what speads up the reaction between H20 and CO2

A

carbonic anhydrase

18
Q

what happens to HCO3- and H+

A

HCO3- enters plasma

H+ - buffered by Hb

19
Q

why is Hb and O2 a bad buffer

A

H+ increases and inhibits the reaction

leads to creation of HCO3- from CO2

20
Q

what is asthmas symptoms

A

wheezing and difficulty breathing due to airway narrowing

21
Q

what is asthma caused by

A

inflammation and bronchoconstriction

due to the release of mediators from inflammatory cells

22
Q

what is COPD caused by

A

chronic airway inflammation with obstruction of airflow due to excessive mucus production

aveoli destruction

23
Q

what kind of infection is pneumonia

A

bacterial or viral infection

24
Q

what causes pneumonia

A

alveoli fill in one or more lobes with pus or fluid

preventing gas exchange

25
Q

what is lung fibrosis due to

A

scarring of the lungs

lungs becoming stiffer and smaller

inhaled irritants e.g. asbestos

26
Q

what is asthma

A

a complex heterogenous disease