Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Immunology and Serology > Lecture: Hypersensitivity > Flashcards

Lecture: Hypersensitivity Flashcards

(58 cards)

Start Studying
1
Q

Exaggerated response to a harmless antigen that results to an injury in the tissue, disease, or even death.

A

Hypersensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Immune System Involved in Type I Hypersensitivity

A

Humoral (IgE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Type I Hypersensitivity has an onset within seconds, gaining its name “”?

A

Immediate Hypersensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The only type of hypersensitivity that is cell-mediated is?

A

Type IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Non-parasite antigens that can stimulate a type I hypersensitivity response; bind to IgE and trigger degranulation of chemical mediators

A

Allergens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Molecular weight of allergens

A

15,000 to 40,000 MW

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Enzyme allergen from the fecal pellets of the dust mite

A

Der P1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cytokines involved in differentiation of B cells

A

IL-4 and IL-13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cytokines involved in development of eosinophils

A

IL-5 and IL-9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cytokines involved in development of mast cells

A

IL-4 and IL-9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cytokines involved in stimulating overproduction of mucus

A

IL-4, 9, 7, 13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Term for the genetic trait to have a predisposition for localized anaphylaxis

A

Atopy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Atopic individuals have higher levels of IgE and eosinophils. True or False?

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

High affinity IgE receptor found on mast cells/basophils/activated eosinophils

A

Fc ε receptors (Fc ε RI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IgE can attach to Mast cells or basophils by Fc receptor, which increases the life span of the IgE, this process is called?

A

Sensitization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Secondary exposure to allergen; allergen binds IgE and cross-links to activate signal with tyrosine phosphorylation, Ca++ influx, degranulation and release of mediators

A

Effector Stage of Hypersensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Mediator responsible for constriction of smooth muscles

A

Histamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Bronchiole constriction can cause?

A

Wheezing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Constriction of intestine can cause?

A

Cramps/diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Mediators formed after activation

A

Secondary Mediators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Pre-formed mediators in granules

A

Primary Mediators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Most severe type of allergy, acute reaction that involves multiple
organs.

A

Anaphylaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Cytokines as Primary Mediators

A

TNF-α, IL-1, IL-6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Chemoattractants for Neutrophils and Eosinophils

25
Th2 cytokines as Secondary Mediators
IL-4, IL-5, IL-13, GM-CSF
26
Serum from Kustner who was allergic to fish was injected to Prausnitz
Passive Cutaneous Anaphylaxis
27
Target organ responds to direct contact with allergen
Localized Anaphylaxis
28
Systemic vasodilation and smooth muscle contraction leading to severe bronchiole constriction, edema, and shock
Systemic Anaphylaxis
29
Repeated injections of allergen to reduce the IgE on Mast cells and produce IgG
Immunotherapy / Desensitization
30
Block histamine receptors
Antihistamines
31
In Vivo Tests
Direct Skin Testing Cutaneous and Intradermal
32
Inject a drop of allergen into the skin, after 15 minutes, check for wheal that is 3 mm higher than the control
Cutaneous/Prick Test
33
More concentration of allergen is used; wheal that is 3 mm higher than the control
Intradermal
34
Measures total IgE
Radioimmunosorbent Test
35
Measures allergen-specific IgE
Radioallergosorbent Test
36
Allows multiple allergens diagnosis with a low sample volume
Microarray Test
37
Type II Hypersensitivity is also known as?
Antibody-mediated cytotoxicity
38
Ab reacts with basement membrane protein → C’ activation → Inflammation → deposition of IgG
Goodpasture’s syndrome
39
Uses polyspecific AHG (Abs to IgG and C3b and C3d) – monospecific AHG
Direct Antiglobulin Test
40
Antigen-antibody immune complexes is involved with what type of hypersensitivity?
Type III Hypersensitivity
41
Serum sickness is usually a permanent immune complex disease with removal of antigen source. True or False?
False, it is transient
42
If neutrophils and macrophages are unable to phagocytize the immune complexes these cells will degranulate in the area of immune complex deposition and trigger inflammation. They are called as?
Frustrated Phagocytes
43
Immune complex or frustrated phagocytes deposited in joints causing local inflammation is known as?
Arthritis
44
Immune complex or frustrated phagocytes deposited in kidneys
Glomerulonephritis
45
Delayed Type Hypersensitivity is known as?
Type IV Hypersensitivity
46
Memory Th1 cells against DTH antigens are generated by dendritic cells during the _?
Sensitization stage
47
Th1 memory cells are activated and produce cytokines: _, _ and _ which cause tissue destruction, inflammation
IFN-γ, TNF-α, and TNF-β
48
Th1 memory cells are activated and produce cytokines: _ that activates CTLs
IL-2
49
Th1 memory cells are activated and produce cytokines: _ for macrophage recruitment
Chemokines
50
Th1 memory cells are activated and produce cytokines: _ for increased monocyte/macrophage
IL-3, GM-CSF
51
The response to poison oak, poison ivy, poison sumac, is a classic Type IV
Contact Dermatitis
52
Allergic disease of the lung parenchyma; AKA Farmer’s lung, Pigeon Breeder’s disease, Humidifier Lung Disease
Hypersensitivity Pneumonitis
53
Soluble Ag from Mtb induce a reaction in people who have/have had tuberculosis
Tuberculin-Type Hypersensitivity
54
Purified filtrate from cell wall of Mtb
Tuberculin Skin Test/PPD
55
Gold standard in testing contact dermatitis
Patch Test
56
0.1 Ag is injected intradermally using a syringe. Test is read at 48 and 72 hours for the presence of induration
Mantoux Method
57
Enzymes as Primary Mediators
Tryptase, chymase, cathepsin
58
Anaphylaxis was coined by _ and _ meaning ""?
Portier and Ritchet Without protection

Immunology and Serology (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions