Less Common Modes of Inheritance Flashcards Preview

Week 40: Chromosomal Abnormalities > Less Common Modes of Inheritance > Flashcards

Flashcards in Less Common Modes of Inheritance Deck (7)
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1

Mosaicism

2 or more populations of cells with different genotypes in one individual

2

X chromosome inactivation

Happens in embryonic development of females
One of the 2 X chromosomes is randomly and permanently inactivated in cells other than egg cells
On average, there are equal proportions of the one from mom and the one from dad

3

Mitochondrial inheritance

Inherited almost exclusively from mother
NS, heart and skeletal muscle are most susceptible

4

Epigenetics

The chemical rnxs that activate/deactivate parts of the genome over development and environment response
Some mechanisms: DNA methylation, histone modifications, microRNAs

5

Imprinting

Imprinted genes are sensitive to environmental signals because there is a single active copy with no backup
Epimutations have greater effects

6

Uniparental disomy

Inheriting all or part of a pair of chromosomes from one parent

7

IUGR

Intrauterine growth restriction