Leukemia

Question 1

What are some early terms associated with leukemia?

Answer 1

White, clone

Question 2

Leukemia is a clonal proliferation of what kind of cells?

Answer 2

Lymphoid or meyloid

Question 3

Clone is the cell population produced from what?

Answer 3

Single progenitor cell

Question 4

True or false Leukemic styles are capable of proliferation and self renewal

Answer 4

True

Question 5

Unregulated proliferating cells spell from where to what?

Answer 5

Bone marrow to peripheral blood

Question 6

What areas can be affected by leukemia?

Answer 6

Spleen, lymph nodes, liver, etc.

Question 7

As tissues and organs are infiltrated by these clones cells it causes tissue/organ what

Answer 7

Failure

Question 8

How does the FAB classify leukemia?

Answer 8

Cell morphology, Seidel chemical results, clinical cafeteria, less than 30% of glass in the bone marrow

Question 9

How does the WHO classify leukemia?

Answer 9

Morphology, Seidel chemistry, immunophenotype cd markers, genetics, clinical features, 20% of blasts in the bone marrow

Question 10

What day with myelogenous leukemia’s have?

Answer 10

Granulocytic, erythrocytic megakaryocytic

Question 11

What do the mono Citic leukemia’s having them?

Answer 11

Monocytes

Question 12

What does lymphoid leukemia is having them?

Answer 12

T cells, B cells

Question 13

What is acute leukemia?

Answer 13

Short duration with lots of amateurs in bone marrow and peripheral blood with increased white blood cells if untreated

Question 14

Chronic leukemia is what?

Answer 14

Long duration with lots of matures in blood marrow in peripheral blood and low to Super increased white blood cells if untreated

Question 15

Which is more common chronic or acute leukemia?

Answer 15

Acute

Question 16

What is some evidence of acute leukemia?

Answer 16

Normal cidlik, normal chromic severe anemia, thrombocytopenia enlarged lymph nodes and spleen low white blood cell count and immunosuppression

Question 17

If untreated what is the prognosis of acute leukemia?

Answer 17

Several weeks to several months but ultimately fatal

Question 18

What does radiation therapy do?

Answer 18

Damages DNA resulting in cell death

Question 19

Drugs for leukemia work on what level?

Answer 19

Molecular

Question 20

Gleevec is what kind of drug

Answer 20

Tyronise kinase inhibitor

Question 21

Rituxab is what kind of drug

Answer 21

Acute lymphoblastic leukemia

Question 22

Chronic leukemia usually occurs when?

Answer 22

Older patients

Question 23

White blood cell count is usually high with what kind of leukemia?

Answer 23

Chronic

Question 24

Prognosis of chronic leukemia is what?

Answer 24

Months to years

Question 25

What are some factors related to the occurrence of leukemia?

Answer 25

Genetic and immuno logical factors, Occupational/environmental exposure, chemical and drug exposure, genetic abnormalities, viral agents

Question 26

What is a common sign of undiagnosed leukemia?

Answer 26

Leukocytosis or increased white blood cells

Question 27

How do we diagnose leukemia?

Answer 27

Morphology, cytochemistry, immunophenotyping, cytogenetics, molecular studies

Question 28

Flow cytomery is used to identify what?

Answer 28

Surface markers

Question 29

Cd 34s, TDT or surface markers for what?

Answer 29

Immatures

Question 30

CD33, 13, 14, 15 are surface markers for what?

Answer 30

Granulocytes/monocyte

Question 31

CD71 is a surface marker for?

Answer 31

Erythroid

Question 32

CD41, 42, 61 is a surface marker for?

Answer 32

Megakaryocytic

Question 33

Cd19, 20, 22 is a surface marker for?

Answer 33

B cells

Question 34

Cd2, Cd3 Cd4 and cd5 is a surface marker for?

Answer 34

T cells

Question 35

Cytogenetics is the study of what?

Answer 35

Chromosome structure and number and inheritance as they relate to a pathological state

Question 36

What is the role of chromosomes?

Answer 36

To transmit genetic material

Question 37

What is the normal karyotype?

Answer 37

22 pairs of autosomes one pair of sex chromosomes for a total of 46 chromosomes

Question 38

What are possible changes in chromosome?

Answer 38

Translocations and deletions inversions and additions

Question 39

P and q stand for what parts of a chromosome?

Answer 39

P stands for short arm, Q stands for a long arm