U 2 P 4

Question 1

CML is classified as what kind of disease?

Answer 1

Myleoproliferative

Question 2

What mutation causes CML?

Answer 2

t(9:22)

Philadelphia chromosome

Question 3

How common is CML and when does it usually appear in life?

Answer 3

Fairly common, around 45 years of age

Question 4

How do we diagnose CML?

Answer 4

Philadelphia chromosome, absent LAP

Question 5

What are the three phases of CML?

Answer 5

Chronic, accelerated, blast

Question 6

What are some CML laboratory data?

Answer 6

Pro fusion of normal appearing granulocytes in all stages of development
WBC 50-500 MAY NEED TO dilute
N/N anemia
Peripheral blood resembles bone marrow aspirate
NRBCS increase as disease progresses
Bone marrow’s smear shows increased megakaryocytes

Question 7

What are some ways to treat CML?

Answer 7

Gleevec, tyrosine kinase inhibitor, my Leo suppressive therapy leukapheresis

Question 8

CLL is what kind of disease?

Answer 8

Lymphoproliferative disease

Question 9

What is the most common form of leukemia in adults?

Answer 9

CLL

Question 10

What is a symptom of CLL exclusive to CLL?

Answer 10

Lymphadenopathy Small lymphocytes that accumulate in bone marrow and spill into peripheral blood

Question 11

What are some laboratory results of CLL?

Answer 11

WBC 20-200
     Peripheral smear
N/N
Lymphocytosis 70 to 95% of lymphocytes
Smudge cells maybe 100 to 200 per 100 white blood cells
CD 5, 19, 20, 23

Question 12

When smudge cells exceed what percent of white blood cells present, and one drop of what to 8drops of blood?

Answer 12

When 15% smudge cells or more at one drop of 22% albumin

Question 13

What are some other forms of CLL?

Answer 13

Hairy cell leukemia, pro lymphocytic leukemia, Waldenström’s macroglobulinemia, lymphosarcoma cell leukemia