Leukemia/Lymphoma Flashcards
1
Q
Cyclophosphamide, Ifosfamide
A
Leukemia/Lymphoma Alkylating agents • *Solid tumors, leukemia, lymphomas - Cell cycle non specific? or G2 phase • Bioactivation by liver MOA • Cross-linking of DNA via alkylation of N7 Guanine à eventual DNA strand breakage ADE • **Hemorrhagic Cystitis (main AE) • Nausea and Vomiting
2
Q
Mesna
A
Leukemia/Lymphoma Chemoprotectant • Adjuvant w/ Alkylating Agents (Cyclophosphamide) • *Prophylactic hemorrhagic cystitis MOA • Protects bladder by binding toxic metabolite (Acrolein) of cyclophosphamide ADE • Abdominal pain • *Diarrhea - *Lack of strength
3
Q
Bleomycin
A
Leukemia/Lymphoma G2 phase specific • *Hodgkin/Non-Hodgkin's lymphoma MOA • Induce free radicals → breaks in DNA strands ADE • **Pulmonary Fibrosis • Hyperpigmentation • *Minimal myelosuppression
4
Q
Methotrexate
A
Leukemia/Lymphoma Antimetabolites: Antifolates S phase specific • *Acute Lymphoblastic Leukemia (ALL) • *Lymphomas MOA • Competitively inhibits dihydrofolate reductase (DFHR) ADE • **Myleosuppression (main one) • Mucositis • Hepatotoxicity
5
Q
Leucovorin
A
Leukemia/Lymphoma Chemoprotectant Reduced Form of Folic Acid (calcium foliate) • **“rescue” Methotrexate toxicity ADE • *Allergic Reactions • Uticaria • *Anaphylactoid reactions (Shock) DRUG INTERACTIONS • Can enhance therapeutic and toxic effects of *5-fluorouracil (5-FU)
6
Q
Vincristine, Vinblastine
A
Leukemia/Lymphoma Vinca Alkaloids Mitosis (M) phase specific • *Solid Tumors, Leukemias, and Hodgkin’s and Non-Hodgkin’s lymphoma MOA • Inhibit tubulin polymerization → disrupts assembly of microtubules → inhibit mitotic spindle formation ADE • **Peripheral Neuropathy • *Myleosuppression • *Nausea and Vomiting
