GOUT

Question 0

Allopurionol

Oxypurinol

Answer 0

• Xanthine oxidase inhibitor
• MOA: DEC purine metabolism=DEC uric acid
• cheaper than Febuxostat
• ADV prolong 1/2 life of immunosuppressants (Azathioprine & 6-Mercaptopurine)=bone marrow depression
• ADV acute gout flare
• used for patients with low/intermediate risk of TSL

Question 1

Colchicine

Answer 1

• anti-inflammatory for gout
• MOA: mitotic spindle poison=inhibits cell division via binding to B-tubulin, interfering with microtubules=interferes with assembly of inflammation complex
• if ALLERGY=intracellular injection with Depo-medrol (corticosteroid suspension)

Question 2

Febuxostat

Answer 2

• Xanthine oxidase inhibitory
• MOA: DEC purine metabolism=DEC uric acid
• ADV prolong 1/2 life of immunosuppressants (Azathioprine & 6-Mercaptopurine)=bone marrow depression
• ADV acute gout flare

Question 3

Probenecid

Answer 3

• Uriosuric drug
• MOA: blocks URAT1 transport and INC uric acid excretion in urine
• ADV acute gout flare

Question 4

Pegloticase

Answer 4

• Uricase drug
• MOA: enzyme turns uric acid into soluble form Allantoin
• injectable PEGylated uric acid specific enzyme for chronic gout
• ADV acute gout flare

Question 5

Rasburicase

Answer 5

• Uricase drug
• MOA: enzyme turns uric acid into soluble Allantoin
• used for patients at high risk for tumor lysis syndrome (TLS)
• ADV acute gout flare