Joint Infections

Question 0

Ceftraixone

Answer 0

• beta lactam

- kills N. gonorrhea, N. meningitides, and Lyme disease

Question 1

Cephalasporin

Answer 1

“Cef- or Ceft-“

• MOA inhibit cell wall synthesis, beta lactam
• no effect on E.coli/Klebs sp ESBP+ or KPC+

Question 2

Ceftazidime

Cefepime

Answer 2

• beta lactam

- kills P. Aeruginosa

Question 3

Cefoxitin

Answer 3

• beta lactam

- kills B. fragilis

Question 4

Cefazolin

Answer 4

• beta lactam

- kills MSSA

Question 5

Ceftaroline

Answer 5

• beta lactam

- only beta lactam that kills MRSA

Question 6

Daptomycin

Answer 6

• non beta lactam
• kills MRSA
• alters cell membrane permeability by binding to membrane and causes rapid depolarization=inhibits protein, DNA, RNA synthesis=cell death
• ineffective for pneumonia
• IV only
• ADV Myopathy (muscle weakness disease), monitor CPK levels

Question 7

Linezolid

Tedizolid

Answer 7

• non beta lactam
• kills MRSA
• inhibits protein metabolism by binding to bacterial ribosome and prevents formation of functional 70s complex
• IV and oral
• ADV Serotonin syndrome (drug induced hyperthermia) and diarrhea (C. diff colitis)
• don’t take w/ antidepressants

Question 8

Clindamycin

Answer 8

• non beta lactam
• kills MRSA, B. frags, nec fasc, Gr+/- anaerobes
• inhibits protein synthesis by binding to 50s ribosomal subunit