Leukemias & Lymphomas

Question 1

The most common subtype of AML

Answer 1

M2 (AML with maturation)

Question 2

The characteristic cell that is seen in AML with maturation

Answer 2

Auer rods

Question 3

M3

Answer 3

Acute promyelocytic leukemia

Question 4

M4

Answer 4

Acute Myelomonocytic Leukemia (AMML)

Question 5

The second most common subtype of AML

Answer 5

M4

Question 6

Another name for M4 / AMML

Answer 6

Naegeli monocytic leukemia

Question 7

The reaction of M0 in MPO and SBB stain

Answer 7

Negative

Question 8

M0

Answer 8

Acute myeloid leukemia minimally differentiated

Question 9

M1

Answer 9

Acute myeloid leukemia without maturation

Question 10

M2

Answer 10

Acute myeloid leukemia with maturation

Question 11

Acute myelogenous leukemia associated with disseminated intravascular coagulation

Answer 11

M3 ( Acute Promyelocytic Leukemia -APL)

Question 12

The characteristic cell found in M3

Answer 12

Faggot cell

Question 13

M4E is also known as

Answer 13

Acute myelomonocytic leukemia with increased marrow eosinophils

Question 14

M5

Answer 14

Acute monocytic leukemia

Question 15

Another name for acute monocytic leukemia

Answer 15

Schilling’s Leukemia

Question 16

M5a

Answer 16

Acute monocytic leukemia, poorly differentiated

Question 17

M5b

Answer 17

Acute monocytic leukemia well differentiated

Question 18

M6 origin

Answer 18

Erythrocytic and myelocytic

Question 19

M6

Answer 19

Acute Erythroleukemia

Question 20

M7

Answer 20

Acute megakaryocytic leukemia

Question 21

Stain required for M7

Answer 21

Factor VIII stain

Question 22

Also known as Di Guglielmo’s syndrome

Answer 22

M6

Question 23

Anemia in Erythroleukemia

Answer 23

Macrocytic, normochromic

Question 24

M5 subtype seen in children

Answer 24

M5a (Acute monocytic leukemia, poorly differentiated)

Question 25

M1 M2 M3 M4 reaction with MPO, SBB, and SE

Answer 25

+

Question 26

M5 reaction with MPO, SBB, and SE

Answer 26

-

Question 27

Positive reaction for M5

Answer 27

A-naphthyl butyrate esterase and A-naphthyl acetate esterase

Question 28

Positive reaction for M4

Answer 28

All except Factor VIII

Question 29

WHO classification I

Answer 29

AML with certain genetic abnormalities

Question 30

WHO classification II

Answer 30

AML with myelodysplasia-related changes

Question 31

WHO classification III

Answer 31

AML related to previous chemotherapy or radiation

Question 32

WHO classification IV

Answer 32

AML Not otherwise specified

Question 33

WHO classification V

Answer 33

Myeloid Sarcoma / Granulocytic sarcoma / Chloroma

Question 34

WHO classification VI

Answer 34

Myeloid proliferations related to down syndrome

Question 35

WHO classification VII

Answer 35

Acute Leukemias of Ambiguous lineage

Question 36

Chronic myelogenous leukemia is also known as

Answer 36

Chronic granulocytic leukemia

Question 37

CML is characterized by the presence of this chromosome

Answer 37

Philadelphia chromosome

Question 38

t(9;22) gene product

Answer 38

BCR-ABL1 fusion gene (contained in the Philadelphia chromosome)

Question 39

The presence of the Philadelphia (Ph1) chromosome signifies a good/bad prognosis?

Answer 39

Good prognosis

Question 40

Used to differentiate Leukemoid reaction from CML

Answer 40

LAP/ NAP test (Leukocyte neutrophil alkaline phosphatase test)

Question 41

Leukemoid reaction frequently refers to this type of cell

Answer 41

Neutrophils

Question 42

The method utilized for the LAP test

Answer 42

Kaplow's method

Question 43

A high lap score indicates LR/CML?

Answer 43

Leukemoid reaction

Question 44

Normal Kaplow's score

Answer 44

20-100

Question 45

Disorders with increased KAPLOW'S SCORE

Answer 45

``` PITI Polycythemia Vera Infections Third Trimester of pregnancy Intoxication ```

Question 46

Disorders with DECREASED KAPLOW'S SCORE

Answer 46

CML Paroxysmal Nocturnal Hemoglobinuria Sideroblastic Anemia Myelodysplastic syndromes