Lewis Blood Group System Flashcards
(19 cards)
The Lewis Blood Group System is designated by ISBT as number
007
The LE locus is found on chromosome…
19
These Lewis antigens are belived to be amorph
Le
le
lele gene
Le(a-b-)
What are the two main antigens of the Lewis Blood Group System (007)?
Le^a
Le^b
What are the possible phenotypes of the Lewis blood system (007)?
Le(a+b-)
Le(a-b+)
Le(a-b-)
Le(a+b+) very rare
Nonsecreator Le genes make these antigens
Le^a
Secretor Le genes make these antigens
Le^b
This antigen is found on all RBCs which are Le(a+b-) and Le (a-b+)
Le^ab
How are Lewis (007) antigens expressed at birth?
Minimal
Lewis blood group (007) antigens are NOT membrane bound. They are
adsorbed from plasma onto RBCs (glycolipids)
Lewins blood group antigens are carried by
glycolipids
The level of Le antigens detectable on RBCs are influenced by
ABO genes inherited
The Le gene produces 1-4 fucosyltransferase to add frucose to _____ structures only.
Type 1
These antigens are found in both plasma and secreations
Lewis antigens
Lewis substances on type1 chains in plasma and in secreations are the same, but the ____ molecule is different
Carrier molecule
What are the two Lewis Blood Group (007) thaqt interact but are at different loci?
Se(FUT2)
Le(FUT3)
This gene enables A, B, and H, antigens to be secreted by coding for the enzyme …
1-2 fucosyltransferase
The inheritance of at least one FUT2 gene (Sese, SeSe) allows for
ABH antigen secretions
