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MD2 OLIVIA > LFTs > Flashcards

Flashcards in LFTs Deck (18)
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1
Q

What are tested in LFTs?

A
  1. Protein
    1. Albumin
    2. Bilirubin
    3. ALT
    4. AST
    5. GGT
    6. ALP
2
Q

For GGT, ALP, AST, ALT and LD, which are membrane derived and which are derived from the cytoplasm?

A

ALP and GGT are from membrane

AST, ALT and LD are from the cytoplasm

3
Q

Where else can you find AST?

A

mitochondria

4
Q

What is normally raised in biliary disease? e.g. gallstones

A

ALP and GGT

5
Q

What do we normally see in alcoholic induced liver damage? in regards to LFT

A

raised GGT because alcohol induces GGT

6
Q

What do we see in the LFT that may indicate liver necrosis?

A

Raised ALT, AST, LD

7
Q

Where else is ALP found?

A

Bone, placenta

8
Q

What is the AST and ALT halflife?

A

AST= 18 hrs; ALT= 36 hrs

9
Q

what does AST>ALT usually indicate? and ALT> AST?

A

AST>ALT–> may indicate acute alcohol/toxin injury

ALT> AST may indicate chronic condition

10
Q

Which of the LFTs is liver specific?

A

ALT

11
Q

What is ALTs normal role?

A

Converts alanine to pyruvate in the CORI cycle

12
Q

What does an ALT level of 5000 mean?

A

1/2 of the liver has died

13
Q

What is the normal role of AST?

A

Converts aspartate and glutamate to oxaloglutarate and oxaloacetate in the KREB cycle
AST in the cytoplasm and mitochondria helps with oxaloacetate transfer into the mitochondria.

14
Q

What will be the difference in GGT and ALP in intrahepatic biliary obstruction and extra hepatic biliary obstruction?

A
Intrahepatic= GGT + ALP +
Extrahepatic= GGT +++ ALP +++
15
Q

What are some drugs that can harm the liver?

A

Statin, anti-epileptic drugs, ethanol, paracetamol, antibiotics, allopurinol

16
Q

Normal range for ALT, AST and Bilirubin?

What about GGT and ALP?

A

ALT

17
Q

which one out of INR and albumin is the first to be affected?

A

INR

18
Q

AMA +ve indicates what?

A

primary biliary cholangitis