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Flashcards in Iron studies Deck (17)
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1
Q

what are the roles of iron in the body?

A

oxygen carriers, oxygen storage, energy production, erythropoeisis

2
Q

How many iron per hb?

A

4

3
Q

What is the role of ferritin? what is the role of transferrin?

A

Ferritin= iron storage Fe2+; Transferrin= iron transport Fe 3+

4
Q

what is the % saturation of transferrin with iron?

A

40%

5
Q

what is the significance of the HFE receptor?

A

It controls the transferrin receptor, and how much iron is transported. Regulates hepcidin. So a mutation in HFE –> haemachromatosis (deficiency in hepcidin)

6
Q

Why does high iron levels lead to low transferrin levels?

A

Iron in the cell binds to Iron Responsive Element (binding protein). This makes the binding protein NOT BIND to the mRNA of transferrin. Hence the transferrin becomes unstable and is consumed.
Conversely, If there is low iron, then the binding protein –> binds to mRNA of transferrin–> production of transferrin

7
Q

what is iron deficiency?

A

lack of iron for physiology

8
Q

What are some physiological losses of iron?

A

Menses, sloughing of gut cells, sweat, pregnancy

9
Q

what are some pathological losses of iron?

A

gut ulceration, tumours, hookworm infection, malaria

10
Q

What type of anaemia is iron deficiency anaemia?

A

microcytic, hypochromic

11
Q

What is the levels of iron, ferritin, TF and Sat TF in iron excess?

A

High iron, low transferrin, high ferritin, high sat TF

12
Q

What is the levels of iron, ferritin, TF and Sat TF in iron deficiency?

A

low iron, high TF, low ferritin, low sat TF

13
Q

What is the levels of iron, ferritin, TF and Sat TF in inflammation?

A

low iron, low TF, low sat TF, high ferritin

14
Q

how much iron do we lose normally each day?

A

1-2mg

15
Q

how much iron is in our body normally

A

4g

16
Q

Role of hepcidin

A

inhibits iron release into plasma from dietary uptake through gut, release of stored iron in macrophages and release of stored iron from hepatocytes in liver

17
Q

what happens to hepcidin levels during erythropoiesis?

A

suppressed hepcidin (reduced hepcidin synthesis by hepatocytes) allows for more iron to aid erythropoesis