Flashcards in Lipid Metabolism: FA Degradation Deck (10):
Which FAs can easily pass through the mitochondria and which ones can't? What is the protocol for the FAs that cannot pass?
SCFAs + MCFAs can pass through
LCFAs can't ; Protocol--> go to peroxisomes to be broken down into degradable form--> sent to mitochondria for continued Beta-Oxidation
What is the general step for FA oxidation?
1.) FA needs to be broken down by lipases
2.) FA needs to enter the mitochondria via rate-limiting step of Fatty Acyl-CoA Synthetase
3.) **Carnitine Acyl Transferase I/ Carnitine Palmitoyl Transferase I will change the CoA--> Carnitine so it can get in through to matrix
4.) Carnitine Acyl Translocase I will push into the Matrix
5.) Carnitine Palmitoyl Transferase II/ Carnitine Palmitoyl Transferase II will change the Carnitine--> CoA
6.) Carnitine will go through the Carnitine Acyl Translocase I back to the intermembrane space
Once the FA chain is in the matrix, what are the general steps for the breakdown of one unit of Acetyl CoA?
What is the net breakdown of 1 Acetyl CoA release?
1 Acetyl CoA
1 NADH--> ETC Complex I
1 FADH2 --> ETC Complex II (CoQ/Ubiquinone)
What are the different types of Acyl-CoA dehydrogenase and what does it do?
It catalyzes the first oxidation of the Beta Oxidation in the matrix (Acyl-CoA Dehydrogenase):
What happens during odd-chain oxidation in the mitochondria?
The resulting molecule that becomes produced is Propional-CoA (3-C):
Carboxylates Proionyl CoA (3C)--> Methylmalonyl-CoA (4C)
***A MethylMalonyl-CoA Mutase converts:
Methylmalonyl-CoA--> Succinyl CoA
*Succinyl CoA then falls into the TCA cycle
What is the process for unsaturated FAs for degradation?
Reductase followed by Isomerase to get it to Saturated State!
What happens when their is defect in MCAD?
Their is a halt in Beta Oxidation which results in the sole use of Glycogen via glucose release
What happens when the body starves?
Ketone body from conversion of Acetyl CoA:
1.) Acetoacetate (23 ATP) (24 -1= 23 for synthesis)
2.) Hydroxybutyrate (26 ATP)
3.) Acetyl CoA (24 ATP)