Flashcards in Mitochondrial Bioenergetics Deck (12)
Is PDC active when phosphorylated or dephosphorylated?
Just like Acetyl CoA Carboxylase, the Pyruvate Dehydrogenase Complex MUST be DEPHOSPHORYLATED for the enzyme to work!!!!!!
What happens if the PDC shuttle doesn't work?
You can't generate Acetyl-CoA as readily. Lactic Acidosis occurs as the body switches to anaerobic respiration in a means to try to make energy.
*** increase lactate--> increase lactic acid--> increase H+ in blood
What phosphorylates or deactivated the PDH Complex?
(-) NADH, (-) ATP, (-) Acetyl CoA --> PHOSPHORYLATION
What dephosphorylates/activates the PDH Complex?
(+) NAD+, (+)ADP, (+) Pyruvate, (+) AMP
What are the major products of the TCA cycle alone not including the PDC?
What are the energy expenditures for the reduced coenzymes of the TCA cycle?
GTP- 1 ATP
What is the rate limiting step in TCA Cycle?
What will happen if there is an excess of alpha-ketoglutarate?
It will prohibit ISOCITRATE DEHYDROGENASE, the RATE-LIMITING STEP OF TCA CYCLE!!!!!!!!!!!!!!!!!!!
What are the mobile carriers in ETC?
Mobile Carriers include:
1.) Quinone (Between Complex II and Complex III)
2.) Cyt C (Between Complex III and IV)
Which complexes receive which electrons?
Complex I -> NADH electrons
Complex 2-> FADH2 electrons
Oxidative phosphorylation is regulated by which two things?
1.) 02 levels
2.) ATP: ADP Ratio