Lipid Testing and Cardiac Risk Assessment Flashcards
Types of Lipids
Fatty Acids
Glycerol Esters
Triglycerides
Phospholipids
Fatty Acids Info
Short, medium, & long chains linear molecules that are major constituents of triglycerides and phospholipids (Saturated, Monounsaturated, Polyunsaturated)
Found in cell membranes
Components of hormones and vitamins
Glycerol Esters Info
Triglycerids: Glycerol ester comprised of glycerol and 3 fatty acid molecules
Phosphoglycerides: Glycerol esters/phosphoric acid group and 3 fatty acid molecules
- Lecithin: cholin molecule
- Cardiolipins
Triglycerides Info
Form oils at room temperature if plant based, solid structure when animal based
95% of fats shored in adipose tissues
Transported in body as chylomicrons and very low density lipoproteins (VLDL)
Metabolism involves releasing fatty acids to the cells for energy, then recycling the glycerol into triglycerides
Lipase, lipprotein lipase, epinephrine, and cortisol breakdown triglycerides
Phospholipids Info
3rd position on the glycerol backbone contains a phospholipid head
Phospholipid head group determines the phospholipid type
Are a major constituent of cell membranes and outer shells of lipoprotein molecules
Phosphatidylcholine
Lecithin
Most common phospholipid
Has a choline head
Amphipathic lipid molecules
Found on surface of lipid layers
Hydrophilic head faces outward
Fatty acid chains face inward
Sphingosine derivatives
Sphingomyelin
Important for normal lung function along with lecithin
Keeps alveoli distended
Cholesterol Info
Unsaturated sterol alcohol found exclusively in animals
Synthesized from acetyl-CoA in microsomal and cystosolic compartments of cells
Amphpathic lipid found on surface of lipid layers along with phospholipids
Also exists in highly polar esterified form known as Cholerteryl ester
Not readily catabolized by most cells and does not serve as energy source for body
Elevations correlate with coronary artery disease from plaque formation
Cholesterol Functions
Cell membrane structural component
Bile acid precursor
Steroid hormone precursor
Sources of Cholesterol
Exogenous
Endogenous
- 70% in skin, adipose tissue and muscle cells
- 30% is in transport in form of lipoproteins (LDL & HDL)
Lipoproteins info
Lipids packaged in a micelle of cholesterol, triglyceride, phospholipids and protein
HDL
High density lipoprotein
Prefer to see this in high numbers
LDL
Low density lipoprotein
Not as good at carrying cholesterol
IDL
Intermediate density lipoprotein (VLDL remnants)
- Normally short lived form in conversion of VLDL to LDL
- In type 3 hyperlipoproteinemia, IDL are detected
- Rare inborn error in which abnormal apo E delays clearance