Lipid Transport

Question 1

Lipids are soluble in _________ solvents

Answer 1

Non-Polar

Question 2

Function of lipids

Answer 2

Source of energy
Signaling
Plasma membrane structure

Question 3

How do Dietary Lipids get to Body cells

Answer 3

Via Lipoproteins

Question 4

Where does chylomicron is produced?

Answer 4

Intestine (small intestine)

Question 5

What is a chylomicron

Answer 5

Molecule composed of Lipid + Lipoprotein

Question 6

Chylomicron express which surface protein

Answer 6

Apo B84

Question 7

Where do Chylomicrons go after formation?

Answer 7

Lympathic channels

Question 8

What happens once a Chylomicron runs out of fatty acids

Answer 8

It is processed by the Liver into cholesterol

Question 9

Where do VLDL is produced?

Answer 9

Liver

Question 10

Which surface protein is representative of VLDL?

Answer 10

Apo B100

Question 11

What is the function of VLDL?

Answer 11

Same as Chylomicron

Question 12

What happens once VLDL has run out of fatty acids

Answer 12

It becomes IDL

Question 13

What routes do IDL have?

Answer 13

1. Processed by liver
2. Formation of LDL (High in cholesterol) and then absorbed by peripheral cells

Question 14

LDL receptor interact with which molecule?

Answer 14

Apo B100

Question 15

What are HDL function?

Answer 15

Donates ApoC2 and ApoE to chylomicron and VLDL

Question 16

What is ApoC2 function?

Answer 16

• Activation of Lipoprotein Lipase = Breakdown of TG into FA
• Let FA enter into pheripheral cells

Question 17

What is ApoE function?

Answer 17

Allows reuptake of remmant lipoproteins for recycling in the Liver

Question 18

How does an inmature HDL becomes a Mature HDL?

Answer 18

Via LCAT enzyme (Activated by Lipoprotein A1)

Question 19

Apo B48 function

Answer 19

Transport of Chylomicrons into lymphatics

Question 20

Apo B100 function

Answer 20

Binds to LDL for uptake of LDL by peripheral cells (ENDOCITOSIS)

Question 21

Abetalipoproteinemia inheritance pattern

Answer 21

Autosomal Recesive

Question 22

Which surface protein is deficient in Abetalipoproteinemia?

Answer 22

ApoB48 / ApoB100

Question 23

Abetalipoproteinemia is characterized by absence of which Lipoproteins?

Answer 23

Chylomicron
VLDL
LDL

Question 24

Clinical features of Abetalipoproteinemia?

Answer 24

Severe fat malabsorption + FTT + Deficiency of fat-soluble vitamins

Question 25

Treatment of Abetalipoproteinemia?

Answer 25

Vitamin E

Question 26

Familial Hypercholesterolemia inheritance pattern

Answer 26

Autosomal Recessive

Question 27

Which surface protein is deficient in Familial Hypercholesterolemia

Answer 27

LDL Receptor or Apo B100

Question 28

Which Lipoproteins are increased in Familial Hypercholesterolemia

Answer 28

LDL (++) Cholesterol

Question 29

Familial Hypercholeterolemia is associated to

Answer 29

Early-onset Atherosclerosis (Accelerated)

Question 30

Familial Hypercholeterolemia is associated to

Answer 30

Early-onset Atherosclerosis (Accelerated)

Question 31

Familial Dyslipidemias follows which kind of inheritance pattern

Answer 31

Autosomal Recessive

Question 32

Dysbetalipoproteinemia is caused by deficient

Answer 32

ApoE

Question 33

Which lipoproteins are affected in Dysbetalipoproteinemia

Answer 33

Increased Chylomicrons and VLDL

Question 34

Dysbetalipoproteinemia clinical features

Answer 34

Accelerated Atherosclerosis + Xanthomas

Question 35

Familial Hypertriglyciridemia is caused by

Answer 35

Excessive production of VLDL

Question 36

Familial Hypertriglyciridemia is associated to

Answer 36

Pancreatitis

Question 37

Hyperchylomicronemia is caused by deficient

Answer 37

Lipoprotein Lipase or ApoC2

Question 38

Hyperchylomicronemia is consistent with elevation of __________

Question 39

Hyperchylomicronemia is consistent with elevation of __________

Answer 39

Chylomicrons / Triglycerides / Cholesterol

Question 40

Hyperchylomicronemia clinical features

Answer 40

Pancreatitis + Xanthomas + Hepatosplenomegaly

Question 41

Hyperchylomicronemia main feature for diagnosis

Answer 41

Creamy layer of fat in supernatant

Question 42

Association between Hyperchylomicronemia and Atherosclerosis

Answer 42

NON-EXISTENT

Question 43

Association between Hyperchylomicronemia and Atherosclerosis

Answer 43

NON-EXISTENT