Lipids (German) week 1 Flashcards Preview

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Flashcards in Lipids (German) week 1 Deck (13):
1

What defines a fatty acid versus a lipid?

-Fatty acid is a carboxylic acid with a long hydrocarbon chain.
-Lipid is one or more fatty acids connected to a linker molecule

2

Fatty Acid types and nomenclature

-Saturated: completely reduced (no dbl bonds)
-Unsaturated: has one dbl bond
-Polyunsaturated: has more than one dbl bond
Nonmen: # of C's:# of dbl bonds(where dbl bonds are) then Cis with name of acid
eg: 18:1(∆9) cis-9-Octadecenoic acid

3

Are double bonds in lipids Cis or Trans in humans?

only CIS

4

Physical properties of fatty acids

-melting point increases with the # of Carbons in chain.
-melting point decreases with the # of dbl bonds

5

4 Types of lipids

storage lipids ( triglycerides)
phospholipids
sphingolipids
glycolipids

6

Storage lipids: Tirglyceride properties

-contain glycerol for linker
-saturated, unsaturated, polyunsaturated
-non-polar
-NOT in biological mems
-Energy dense
-Primary energy storage
-Primary source for many organ systems

7

Transfers of free fatty acids and triglycerides

-chylomicron-transfers lipid to blood from GI
-Albumin transfers bloodstream free fatty acids
-Lipoproteins transfer triglycerides from adipose tissue to other cells

8

Plasma membrane lipids and Fatty acids
3 major membrane lipids

Phospholipids
Sphingolipids
Glycolipids
also contains sterols or cholesterol but are considered fatty acids

9

Phospholipid make up

-phosphate group
-glycerol or sphingosine linker
-Major constituent of most animal plasma membranes

10

Sphingolipids make up

-one sphingosine, one fatty acid
-Phosphate, glucose, or polysaccharide head group components
-Membrane components, direct signaling activity
-Amine with fatty acid and head group is the general structure

11

Glycolipids

-anchor proteins to membranes
-Involved in cellular identification
-Tied to many diseases

12

Sterols aka membrane fatty acids

-Major membrane component
-Increases membrane rigidity
-reduces mem permeability
lipid raft constituent
Necessary for endocytosis

13

Lipid signaling drives and resolve inflam.
How and what are the components?

Arachidonate is converted to
1. prostoglandins
2. thromboxanes
3. leukotriene
NSAIDs block this and thus reduce inflam.