Lipids Part 3

Question 1

What is fat catabolism?

Answer 1

Breakdown of triglyceride to produce energy

Question 2

List the 7 steps of fat catabolism

Answer 2

1. Mobilization
2. Circulation
3. Uptake
4. Activation
5. Translocation
6. B-oxidation
7. Mitochondrial Oxidation

Question 3

What occur in the step: Mobilization of Fat Catabolism?

Answer 3

• Stored lipids in the form of adipose tissue is “opened up” by the hormone sensitive enzymes: lipase. “Opening up” is the hydrolyses of TG into glycerol backbone and 3FA. FAA and MG are released into the blood

Question 4

What occur in the step: Circulation of Fat Catabolism?

Answer 4

• FFA must bind to albumin to travel in the circulation

Question 5

What occur in the step: Uptake of Fat Catabolism?

Answer 5

-As FFA+albumin travel around body, the target cell (any cell that needs energy) will uptake that FFA to convert it to energy. FFA starts to enter the cell

Question 6

What occur in the step: Activation of Fat Catabolism?

Answer 6

• As FFA enter the cell, Coenzyme A will activate FFA by attaching to it making a compound called FattyAcylCoA
• Activation step requires energy ATP->ADP (-1)

Question 7

What occur in the step: Translocation of Fat Catabolism?

Answer 7

• The movement of Fatty Acyl CoA from cytosol to mitochondria
• Carnitine
• Requires ATP->ADP (-1)
• Total lost thus far is -2ATP
• carnitine takes FAinto mitochondria
  Carnitine translocase needed
  Reactivating by CoA