Liver

Question 1

L1: ______: macrophages of the liver

Answer 1

Kupffer Cells

Question 2

L1: Which etiology is suggested by an infiltrate of eosinophils?

Answer 2

Drug Injury

Question 3

L1: Which etiology is suggested by an infiltrate of plasma cells?

Answer 3

Autoimmune hepatitis

Question 4

L1: Which hepatitis virus? Cannot replicate on its own

Answer 4

D

Question 5

L1: Which hepatitis virus? Contains some dsDNA

Answer 5

B

Question 6

L1: Which hepatitis virus? Never progresses to chronic liver disease

Answer 6

A, E

Question 7

L1: Which hepatitis virus? Transmitted by fecal-oral route

Answer 7

A, E

Question 8

L2: ______: space between hepatocyte and Kupffer cell

Answer 8

Space of Disse

Question 9

L2: _____: amount of fibrous tissue deposition

Answer 9

Stage

Question 10

L2: _____: amount of inflammation and injury

Answer 10

Grade

Question 11

L2: Name 2 common causes of acute hepatitis

Answer 11

Acute viral hepatitis, drug injury

Question 12

L2: Name the chief risk factor associated with cholangiocarcinoma.

Answer 12

Primary Sclerosing Cholangitis

Question 13

L2: Name the chief risk factor associated with hepatocellular carcinoma

Answer 13

Chronic liver disease/Cirrhosis

Question 14

L2: Name the mutated gene in hereditary hemochromatosis.

Answer 14

HFE

Question 15

L2: Name the mutated gene in Wilson’s Disease.

Answer 15

ATP7B (transporter in bile secretion)

Question 16

L2: Which etiology is suggested by an infiltrate of lymphocytes?

Answer 16

Viral hepatitis

Question 17

L2: Which etiology is suggested by an infiltrate of neutrophils?

Answer 17

Steatohepatitis

Question 18

L2: Which hepatitis virus? Associaed with intranasal cocaine use

Answer 18

C

Question 19

L2: Which hepatitis virus? Associated with sexual contact

Answer 19

B

Question 20

L2: Which hepatitis virus? Ground glass hepatocytes with virion inclusions in the endoplasmic reticulum

Answer 20

B

Question 21

L2: Which hepatitis virus? Higher mortality in pregnant women

Answer 21

E

Question 22

L2: Which hepatitis virus? Major cause of chronic liver disease in the US

Answer 22

B

Question 23

L2: Which hepatitis virus? Major cause of chronic liver disease worldwide

Answer 23

C

Question 24

L2: Which hepatitis virus? Progresses to chronic liver disease in 10% of patients

Answer 24

B

Question 25

L2: Which hepatitis virus? Progresses to chronic liver disease in 80% of patients

Answer 25

C

Question 26

L2: Which pathologic pattern? Anti-mitochondrial antibody in 90%; histology shows granulomatous lymphocytic cholangitis

Answer 26

Primary Biliary Cirrhosis

Question 27

L2: Which pathologic pattern? Benign mass-like proliferation of hepatocytes arising from a local vascular flow anomaly

Answer 27

Focal nodular hyperplasia

Question 28

L2: Which pathologic pattern? Benign neoplasm of hepatocytes; most common in women of childbearing age, very low risk of transformation to malignancy

Answer 28

Hepatocellular Adenoma

Question 29

L2: Which pathologic pattern? Cholangiography shows alternating strictures and dilatation of duct; no specific serologic findings

Answer 29

Primary Sclerosing Cholangitis

Question 30

L2: Which pathologic pattern? Elevated IgG and serum autoantibodies

Answer 30

Autoimmune hepatitis

Question 31

L2: Which pathologic pattern? Immune-mediated attack of small caliber bile ducts

Answer 31

Primary Biliary Cirrhosis

Question 32

L2: Which pathologic pattern? Immune-mediated obliterative fibrosis of intrahepatic and extrahepatic bile ducts

Answer 32

Primary Sclerosing Cholangitis

Question 33

L2: Which pathologic pattern? Increased de novo lipogenesis and decreased beta-oxidation

Answer 33

Alcohol-Related Steatohepatitis

Question 34

L2: Which pathologic pattern? Increased lipolysis of visceral fat due to endocrine abnormalities

Answer 34

Non-Alcohol Steatohepatitis

Question 35

L2: Which pathologic pattern? Insidious onset with pruritis appearing before jaundice, most common in middle aged women

Answer 35

Primary Biliary Cirrhosis

Question 36

L2: Which pathologic pattern? Liver disease and neuropsychiatric problems; autosomal recessive inheritance

Answer 36

Wilson's Disease

Question 37

L2: Which pathologic pattern? Major cause of acute liver failure leading to transplant in the US

Answer 37

Acetaminophen Drug Toxicity

Question 38

L2: Which pathologic pattern? Malignant neoplasm of bile ducts

Answer 38

Cholangiocarcinoma

Question 39

L2: Which pathologic pattern? Manifests as liver disease, diabetes, and heart failure; autosomal recessive inheritance

Answer 39

Hereditary Hemochromatosis

Question 40

L2: Which pathologic pattern? Most common malignant liver tumor

Answer 40

Metastases

Question 41

L2: Which pathologic pattern? Most common primary hepatic tumor; usually small and asymptomatic

Answer 41

Hemangioma

Question 42

L2: Which pathologic pattern? Most common primary malignant liver tumor

Answer 42

Hepatocellular carcinoma

Question 43

L2: Which pathologic pattern? Neutrophilic Infiltrates and Mallory bodies

Answer 43

Alcohol-Related Steatohepatitis

Question 44

L2: Which pathologic pattern? Onion-skin periductal fibrosis with progressive disappearance of the bile duct

Answer 44

Primary Sclerosing Cholangitis

Question 45

L2: Which pathologic pattern? PiZZ genotype causing pulmonary emphysema; liver disease in 10% of patients

Answer 45

Alpha-1-Antitrypsin Deficiency

Question 46

L2: Which pathologic pattern? Steatosis and centrilobular fibrosis on histology; caused by alcohol, metabolic syndrome, or drug injury

Answer 46

Steatohepatitis

Question 47

L3: Name 3 causes of chronic hepatitis

Answer 47

Chronic viral hepatitis, autoimmune hepatitis, drug injury

Question 48

L3: Name the top 3 risk factors for Hepatitis C infection

Answer 48

IV drug abuse, multiple sexual partners, recent surgery

Question 49

L4: Name 4 patterns of fibrosis in the liver.

Answer 49

Portal fibrosis, Periportal fibrosis, Bridging fibrosis, Cirrhosis