Liver: Catabolism of lipids + Bile synthesis Flashcards Preview

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Flashcards in Liver: Catabolism of lipids + Bile synthesis Deck (13):
1

In what part of the hepatocytes are triglycerides stored

Cytoplasm

2

In what form are triglycerides deposited in the cytoplasm of hepatocytes

As a single fatty droplet

3

Describe fatty acid catabolism

1. CoA is attached to -COOh molecule at the end of the fatty acid
2. ATP -> AMP + 2Pi
3. Fatty acid-CoA compound undergoes beta-oxidation
4. Acetyl CoA splits off fatty acid
5. 2H+ trasnferred to NAD+ and FAD+
6. FADH and NADH enter OXIDATIVE PHOSPHORYLATION
7. ATP Produced
8. CoA binds to fatty acid + cycle is repeated
9. Continues to lose two carbon atoms per CoA until all has been transferred to CoA
10. Production of Co2 and ATP via Krebs' Cycle + Oxidative Phosphorylation

4

Role of Lipoprotein Lipase

Hydrolyses triglycerides in lipoprotein (chylomicrons and VLDL) to 2 fatty acids and a monoglyceride molecule)

5

Role of Hepatic Lipase

Converted IDL to LDL

6

Where is Hepatic Lipase expressed

Liver and Adrenal Glands

7

Why is LDL more useful than IDL

LDL carries more triglycerides

8

How often is bile secreted

Continuously

9

What hormone is excreted in bile

Steroid hormones

Tip: Cholesterol produces steroid hormones and that is mainly excreted in the bile so, yeah.

10

What happens to bile stored in the gallbladder

Stored + Concentrated

11

Why does bile concentrate in the gallbladder

Due to absorption of Na and Cl

12

Where can the gallbladder be palpated

Lies at right mid-clavicular line at the costal margin

13

What vein connects the liver to the GI Tract

Portal Vein