Local Anesthetic Agents Flashcards
(16 cards)
What is the primary mechanism of action of Lidocaine?
Sodium channel blocker
Lidocaine works by blocking sodium channels, which stabilizes the neuronal membrane.
What is the typical IV bolus dose of Lidocaine for arrhythmia treatment?
0.5-1 mg/kg
This dosage is used for effective treatment of arrhythmias.
What is the onset of action of IV Lidocaine?
1–2 minutes
This rapid onset is crucial in emergency situations.
What is the primary indication for Lidocaine in emergency cardiac care?
Ventricular arrhythmias
Lidocaine is specifically indicated for managing ventricular arrhythmias.
Which of the following is NOT a typical side effect of Lidocaine toxicity?
Hyperglycemia (though indirectly can happen lido with epi)
Common side effects include tinnitus, seizures, and confusion.
Is Lidocaine a class 1b antiarrhythmic?
Yes
Class 1b antiarrhythmics are known for their sodium channel blocking effects.
Does Lidocaine act by enhancing sodium influx into cardiac cells?
No — It blocks sodium channels, decreasing influx.
This mechanism reduces excitability in cardiac tissues.
Can Lidocaine be used as a local anesthetic and as an antiarrhythmic agent?
Yes
Lidocaine has dual roles in medicine.
Is the duration of action of IV Lidocaine typically more than 2 hours?
No — It lasts about 10–20 minutes after an IV bolus.
This short duration necessitates careful dosing.
Is Lidocaine metabolized primarily in the kidneys?
No — It is metabolized in the liver.
Understanding its metabolism is important for dosing in liver impairment.
What is the typical IV bolus dose of Lidocaine for ventricular arrhythmias?
0.5 – 1 mg/kg IV bolus.
This is the same as the dosage for general arrhythmia treatment.
What is the onset of action of Lidocaine when given intravenously?
1–2 minutes
This fast action is essential in acute care settings.
Describe the mechanism of action of Lidocaine.
Lidocaine blocks voltage-gated sodium channels, which stabilizes the neuronal membrane and decreases automaticity in cardiac cells.
This mechanism is vital for its antiarrhythmic effects.
List three signs of Lidocaine toxicity.
Tinnitus, circumoral numbness, seizures, dizziness, confusion.
Monitoring for these signs is crucial during treatment.
In what clinical scenario would Lidocaine be the drug of choice?
Treatment of ventricular arrhythmias, especially in the setting of acute myocardial infarction or during cardiac arrest.
It is particularly effective in these critical situations.
Is Lidocaine as a Local Anesthetic reversible?
Not directly with an “antidote”; but will naturally, administer phentolamine to decrease lidocaine with epi vasoconstriction effects (speed up blood flow), in the case of toxicity with lipid emulsion therapy
This property allows for safe use in various procedures.
