Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

NSU AA Denver Drugs and Inhalational Agents > Muscle Relaxant Agents > Flashcards

Muscle Relaxant Agents Flashcards

(84 cards)

Start Studying
1
Q

What is the standard IV dose of Succinylcholine for rapid sequence intubation in adults?

A

1.0–2 mg/kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the typical onset of action for Succinylcholine after IV administration?

A

30 seconds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How long does the neuromuscular blockade from Succinylcholine usually last?

A

4–6 minutes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the mechanism of action of Succinylcholine?

A

Depolarizing neuromuscular blocker that mimics acetylcholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which of the following is a known dangerous side effect of Succinylcholine?

A

Malignant hyperthermia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

In which of the following scenarios is Succinylcholine contraindicated?

A

Burn injury after 24 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Is Succinylcholine a non-depolarizing muscle relaxant?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Does Succinylcholine have a very short duration of action, typically under 10 minutes?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Is Hyperkalemia a possible side effect of Succinylcholine?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Should Succinylcholine be avoided in patients with a history of malignant hyperthermia?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Is Succinylcholine metabolized by plasma cholinesterase?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Does Succinylcholine cause muscle fasciculations prior to paralysis?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the typical IV dose of Rocuronium for rapid sequence intubation (RSI)?

A

0.6–1.2 mg/kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the approximate onset of action of Rocuronium when used for RSI at high doses?

A

60-90 seconds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How long does the neuromuscular blockade typically last after a standard intubating dose of Rocuronium?

A

30–60 minutes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the mechanism of action of Rocuronium?

A

Non-depolarizing neuromuscular blocker (competitive antagonist)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which of the following drugs can be used to reverse Rocuronium’s effects quickly?

A

Sugammadex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which of the following is an appropriate use for Rocuronium?

A

Muscle relaxation for endotracheal intubation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Is Rocuronium a non-depolarizing neuromuscular blocker?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Does Rocuronium have a faster onset than Succinylcholine?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Does Rocuronium cause muscle fasciculations before paralysis?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Does Rocuronium provide any analgesic or sedative effects?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Is Rocuronium metabolized primarily by the liver?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is the standard IV dose of Rocuronium for rapid sequence intubation?

A

0.6–1.2 mg/kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is the onset time of Rocuronium when given in RSI doses?
60-90 seconds
26
What is the average duration of action for Rocuronium?
30–60 minutes
27
Describe the mechanism of action of Rocuronium.
Rocuronium is a non-depolarizing neuromuscular blocker that competitively inhibits acetylcholine at nicotinic receptors in the neuromuscular junction.
28
List two clinical indications for using Rocuronium.
* Rapid sequence intubation * Maintenance of muscle relaxation during surgery
29
What reversal agent is most specific and rapid for Rocuronium?
Sugammadex
30
Why might Rocuronium be preferred over Succinylcholine in some patients?
It avoids risks like hyperkalemia, malignant hyperthermia, and increased ICP
31
Does Rocuronium provide sedation or pain relief?
No
32
What is the typical dose of Cisatracurium in adults?
0.08-0.12 mg/kg
33
What is the typical onset of action for Cisatracurium at intubating doses?
2–3 minutes
34
What is the approximate duration of action of Cisatracurium?
20–40 minutes
35
What is the primary route of metabolism for Cisatracurium?
Hofmann elimination (organ-independent)
36
In which of the following scenarios is Cisatracurium particularly advantageous?
Both liver and renal failure
37
Is Cisatracurium a depolarizing neuromuscular blocker?
No
38
Can Cisatracurium be used safely in patients with renal or hepatic impairment?
Yes
39
Does the metabolism of Cisatracurium rely heavily on the liver?
No
40
Does Cisatracurium cause histamine release and is associated with hypotension and flushing?
No
41
Does Cisatracurium provide any analgesic or sedative properties?
No
42
What is the standard intubating dose of Cisatracurium?
0.08–0.12 mg/kg
43
What is the typical onset of action for Cisatracurium?
2–3 minutes
44
What is the average duration of action of Cisatracurium?
30–60 minutes
45
How is Cisatracurium metabolized?
Primarily via Hofmann elimination, which is temperature and pH-dependent and does not rely on liver or kidney function.
46
Name two clinical advantages of using Cisatracurium over other neuromuscular blockers.
* Minimal histamine release * Safe use in liver or renal failure
47
Does Cisatracurium provide sedation or analgesia?
No
48
When might Cisatracurium be preferred over Rocuronium?
In patients with renal or hepatic dysfunction, or when longer-term neuromuscular blockade is needed in the ICU.
49
What is the typical intubating dose of Vecuronium in adults?
0.08-0.12 mg/kg
50
What is the average onset time of Vecuronium?
3-5 minutes
51
How long does the effect of a single dose of Vecuronium typically last?
30-60 minutes
52
What is the mechanism of action of Vecuronium?
Blocks acetylcholine at the neuromuscular junction
53
In which of the following situations is caution advised when using Vecuronium?
Hepatic impairment, Renal failure, Neuromuscular diseases
54
Is Vecuronium a depolarizing neuromuscular blocking agent?
No
55
Does Vecuronium have significant cardiovascular side effects such as bradycardia and hypotension?
It has minimal cardiovascular effects.
56
Is the elimination of Vecuronium dependent on both hepatic and renal function?
Yes
57
Does Vecuronium cause histamine release?
It has little to no histamine release.
58
Is Vecuronium suitable for use in rapid sequence induction?
No
59
What is the standard intubating dose of Vecuronium?
0.08–0.12 mg/kg IV
60
What is the typical onset time of action of Vecuronium?
3-5 minutes
61
What is the average clinical duration of Vecuronium?
30–60 minutes
62
What is the mechanism of action of Vecuronium?
It competitively inhibits acetylcholine at nicotinic receptors at the neuromuscular junction, preventing depolarization and muscle contraction.
63
Why must Vecuronium be used cautiously in patients with liver or kidney dysfunction?
Because it is partially metabolized by the liver and excreted by the kidneys, leading to prolonged effects.
64
List two advantages of Vecuronium.
* Minimal cardiovascular effects * No histamine release
65
Can Vecuronium be used for maintenance of neuromuscular blockade in the ICU?
Yes
66
Does Vecuronium provide any analgesic or sedative properties?
No
67
What is the typical intubating dose of Pancuronium in adults?
0.08-0.12 mg/kg
68
What is the average onset time of Pancuronium?
2-3 minutes
69
How long does a single dose of Pancuronium typically last?
60–90 minutes
70
Which of the following is a notable side effect of Pancuronium?
Tachycardia
71
Pancuronium is best avoided in which patient population?
Patients with tachycardia or heart failure
72
Is Pancuronium a depolarizing neuromuscular blocking agent?
No
73
Does Pancuronium have vagolytic properties, which may lead to increased heart rate?
Yes
74
Is Pancuronium primarily eliminated via the liver?
No
75
Does Pancuronium have a short duration of action, making it ideal for short procedures?
No
76
Does Pancuronium release histamine?
No
77
What is the standard intubating dose of Pancuronium?
0.08–0.12 mg/kg IV
78
What is the typical onset time of Pancuronium?
2-3 minutes
79
What is the average duration of action of Pancuronium?
60–90 minutes
80
What is the mechanism of action of Pancuronium?
It competitively inhibits acetylcholine at nicotinic receptors at the neuromuscular junction, preventing muscle contraction.
81
Why might Pancuronium cause tachycardia?
Because of its vagolytic (antimuscarinic) effects, which inhibit parasympathetic (vagal) tone.
82
In what scenario might Pancuronium be especially useful?
In patients with bradycardia or when prolonged paralysis is required.
83
Name two clinical uses of Pancuronium.
* Facilitation of intubation * Maintenance of muscle relaxation during long surgeries or mechanical ventilation
84
What is a contraindication or caution for using Pancuronium?
Patients with tachyarrhythmias, congestive heart failure, or renal insufficiency.

NSU AA Denver Drugs and Inhalational Agents (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions