Long-Term Control Medications in Asthma and COPD - Biologics

Question 1

omalizumab brand name

Answer 1

Xolair

Question 2

omalizumab dosage forms

Answer 2

• prefilled syringe
• vial reconstitution

Question 3

omalizumab dosing ages

Answer 3

≥ 6-11 and adults

Question 4

what mechanism does omalizumab use?

Answer 4

Anti-IgE
inhibit IgE binding to receptors on mast cells and basophils, inhibit mediator release and attenuation of early- and late-phase allergic response

Question 5

mepolizumab brand name

Answer 5

Nucala

Question 6

mepolizumab dosage forms

Answer 6

• auto-injector
• vial for reconstitution

Question 7

mepolizumab dosing ages

Answer 7

≥ 6-11 and adults

Question 8

reslizumab brand name

Answer 8

Cinqair

Question 9

reslizumab doseage forms

Answer 9

vial soultion

Question 10

reslizumab dosing ages

Answer 10

adults

Question 11

benralizumab brand name

Answer 11

Fasenra

Question 12

benralizumab dosage form

Answer 12

• auto-injectior
• prefilled syringe

Question 13

benralizumab dosing ages

Answer 13

adults

Question 14

mepolizumab, reslizumab, and benralizumab are all ___.

Answer 14

anti-IL5
blocks binding of IL-5 to the alpha chain of the IL-5 receptor complex, which results in reduced production and survival of eosinophils

Question 15

depilumab brand name

Answer 15

Dupixent

Question 16

dupilumab dosage form

Answer 16

injection

Question 17

dupilumab dosing ages

Answer 17

adults

Question 18

omalizumab adverse effects

Answer 18

• headache
• injection site reactions
• arthralgias
• thrombocytopenia
• pharyngitis
• sinusitis
• upper respiratory tract infections

Question 19

omalizumab boxed warning

Answer 19

anaphylaxis

Question 20

omalizumab clinical pearls:
* do not give more than ___ mg per injection site
* FDA approved for moderate to severe ___ in patients with a positive skin test or reactivity to a ___ and symptoms that are inadequately controlled with ___

Answer 20

• 150 mg
• asthma, perennial aeroallergen, ICS

Question 21

mepolizumab adverse effects

Answer 21

• headache
• injection site reactions
• arthralgias
• Herpes Zoster infection

Question 22

mepolizumab clinical pearls:
* Precaution: ___
* Available as an in-clinic or at-home injection
* Indicated for add-on maintenance treatment of patients with severe ___ with an ___ phenotype

Answer 22

• anaphylaxis
• asthma, eosinophilic

Question 23

reslizumab adverse effects

Answer 23

• injection site reactions
• myalgias
• increased
  creatinine phosphokinase

Question 24

reslizumab boxed warning

Answer 24

anaphylaxis, malignancies

Question 25

reslizumab clinical pearls: * Indicated for add-on maintenance treatment of patients with ___ asthma with an ___ phenotype

Answer 25

* severe * eosinophilic

Question 26

benralizumab adverse effects

Answer 26

* injection site reactions * antibody development * headache * pharyngitis * fever

Question 27

benralizumab clinical pearls * Precaution: ___ * available as an in-clinic or at-home injection * Indicated for add-on maintenance treatment of ___ asthma in adults and children ≥12 years of age with an ___ phenotype * Acts on IL-5 ___ while others act on IL-5

Answer 27

* anaphylaxis * severe, eosinophilic * receptors

Question 28

dupilumab adverse effects

Answer 28

* Injection site reactions * antibody development * arthralgias * conjunctivitis

Question 29

dupilumab clinical pearls * Precaution: ___ * Available in pre-filled syringe for in-office or at home administration * Indicated as an add-on maintenance treatment in patients with ___ to ___ asthma aged 12 years and older with an ___ phenotype or with oral ___ dependent asthma.

Answer 29

* anaphylaxis * moderate, severe * eosinophilic, corticosteroid

Question 30

what mechanism does dupilumab use? Anti-___: blocks binding of IL/4 to reduce eosinophil trafficking and ___ reactions while also blocking ___ to reduce mucus secretion and airway remodeling

Answer 30

* IL4/IL13 * IgE * IL-13