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PHRM 825 > ANS-1,2 > Flashcards

ANS-1,2 Flashcards

Autonomic Nervous System 1/9/23

1
Q

Which receptors use the Gq pathway?

A

M1, M3, M5, a1

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2
Q

Which receptors use the Gi pathway?

A

M2, M4, a2

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3
Q

Which receptors use the Gs pathway?

A

B1, B2, B3

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4
Q

What receptor is a 5 subunit sodium ion channel

A

Nicotinic

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5
Q

Heart: rate of contraction - adrenergic response and receptor

A

increase rate of contraction, B1>B2

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6
Q

Heart: rate of contraction - cholinergic response and receptor

A

decrease rate of contraction, M2

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7
Q

Heart: force of contraction - adrenergic response and receptor

A

increase force of contraction, B1>B2

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8
Q

Heart: force of contraction - cholinergic response and receptor

A

decrease force of contraction, M2

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9
Q

Arteries - adrenergic response and receptor

A

vasoconstriction, a1

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10
Q

Veins - adrenergic response and receptor

A

vasoconstriction, a1, a2

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11
Q

Blood flow to Skeletal Muscle - adrenergic response and receptor

A

vasodilation, B2

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12
Q

Endothelium - cholinergic response and receptor

A

release of EDRF (endothelium derived relaxing factor), M3

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13
Q

Lung: bronchiolar smooth muscle - adrenergic response and receptor

A

bronchodilation, B2

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14
Q

Lung: bronchiolar smooth muscle - cholinergic response and receptor

A

bronchoconstriction, M2, M3

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15
Q

Genitourinary Smooth Muscle: Bladder Wall - adrenergic response and receptor

A

relaxation, B3

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16
Q

Genitourinary Smooth Muscle: Bladder Wall - cholinergic response and receptor

A

contraction, M3

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17
Q

Genitourinary Smooth Muscle: Ureter - adrenergic response and receptor

A

contraction, a1

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18
Q

Genitourinary Smooth Muscle: Ureter - cholinergic response and receptor

A

relaxation, M3

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19
Q

Genitourinary Smooth Muscle: Sphincter - adrenergic response and receptor

A

contraction, a1

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20
Q

Genitourinary Smooth Muscle: Sphincter - cholinergic response and receptor

A

relaxation, M3

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21
Q

Genitourinary Smooth Muscle: Uterus (pregnant) - adrenergic response and receptor

A

relaxation (B2) & contraction (a1)

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22
Q

Genitourinary Smooth Muscle: Uterus (pregnant) - cholinergic response and receptor

A

variable, M3

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23
Q

Genitourinary Smooth Muscle: Penis/Vas Deferens - adrenergic response and receptor

A

ejaculation, a1

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24
Q

Genitourinary Smooth Muscle: Penis/Vas Deferens - cholinergic response and receptor

A

erection, M3

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25
Skin: Hair follicles - adrenergic response and receptor
contraction, a1
26
Skin: smooth muscle -adrenergic response and receptor
piloerection, a1 (goosebumps)
27
Sweat Glands: thermoregulation - adrenergic response and receptor
increased secretion, M3 (weird exception)
28
Sweat Glands: Apocrine (stress) - adrenergic response and receptor
increased secretion, a1 (NE is neurotransmitter) (nauuuurrrr my hands are sweaty)
29
GI Tract: salivary glands - adrenergic response and receptor
increased secretion, a1
30
GI Tract: salivary glands - cholinergic response and receptor
increased secretion, M3
31
GI Tract: Smooth Muscles: Walls - adrenergic response and receptor
relaxation, a2, B2 (no need for digestion)
32
GI Tract: Smooth Muscles: Walls - cholinergic response and receptor
contraction, M3 (rest and digest)
33
GI Tract: Smooth Muscles: Sphincters - adrenergic response and receptor
contraction, a1
34
GI Tract: Smooth Muscles: Sphincters - cholinergic response and receptor
relaxation, M3
35
GI Tract: Secretion - adrenergic response and receptor
decreased secretion, a2 (don't need digestive juice)
36
GI Tract: Secretion - cholinergic response and receptor
increased secretion, M3 (need digestive juice)
37
Liver - adrenergic response and receptor
glycogenolysis and gluconeogenesis, a1, B2
38
Fat Cells - adrenergic response and receptor
lipolysis, a1, B1, B2, B3
39
Kidney - adrenergic response and receptor
increase renin secretion, B1
40
Pancreas - adrenergic response and receptor
decrease insulin, a2
41
Eye: Iris: Radial Muscle - adrenergic response and receptor
contraction, a1 (mydrasis=pupil dilation)
42
Eye: Iris: Circular Muscle - cholinergic response and receptor
contraction, M3 (miosis=pupil constriction)
43
Eye: Ciliary Muscle - adrenergic response and receptor
relaxation, B2 (relaxing ciliary muscle = closing drainage = more intraocular pressure)
44
Eye: Ciliary Muscle - cholinergic response and receptor
contraction, M3 (contracting ciliary muscle = opening drain = less intraocular pressure)
45
Eye: Ciliary Epithelium - adrenergic response and receptor
increased secretion, B2 (makes more aq goo)
46
Eye: Lacrimal glands - adrenergic response and receptor
mucus and enzymes, a1
47
Eye: Lacrimal glands - cholinergic response and receptor
watery tears, M3
48
SNS and PSNS typically oppose each other, EXCEPT when it comes to _________
male sex organs SNS - ejaculation, a1 PSNS - erection, M3
49
______ and ______ are controlled by SNS only
arteries and veins
50
Pilocaprine Mechanism
M3 agonist, contracts ciliary muscle and allows for drainage (decreases intraocular pressure)
51
Brimonidine Mechanism
a2 agonist, ciliary body inhibits production of aq goo and increase drainage (decreases intraocular pressure)
52
Timolol Mechanism
B antagonist, inhibits secretion of aq goo from ciliary epithelium (decreases intraocular pressure)
53
Latanaprost Mechanism
prostaglandin PGF2 analog, increase drainage of aq goo (decreases intraocular pressure)
54
What is this?
ACh
55
What is this?
Muscarine
56
What is this?
Nicotine
57
What is this?
Norepinephrine
58
What is this?
Epinephrine
59
preganglionic neurons in the PSNS are short or long?
Long
60
preganglionic neurons in the SNS are short or long?
Short
61
Transmitter in all PSNS postganglionic neurons is
ACh
62
Transmitter in most SNS postganglionic neurons is
NE
63
In addition to NE, the SNS also utilizes which neurotransmitters?
ACh (sweat glands), Epinephrine (adrenal medulla), Dopamine (renal vasculature)
64
Primary transmitter of all preganglionic neurons is
ACh
65
SNS Exception - Sweat: transmitter responsible for nervous sweaty palms
NE
66
SNS Exception - Sweat: transmitter responsible for thermoregulation (cooling sweat)
ACh
67
SNS Exception: Adrenal - Preganglionic neurons synapse directly on to ______
the adrenal gland (no postganglion)
68
SNS Exception: Adrenal - the adrenal glands release _______ into the systemic circulation
Epinephrine
69
SNS Exception: Kidneys - affected by ______ which is locally synthesized (not ANS)
Dopamine

PHRM 825 (49 decks)

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