Low Grade Non-Hodgkin Lymphomas

Question 1

Name the 4 low grade lymphomas.

Answer 1

Follicular Lymphoma
SLL/CLL
Marginal Zone lymphoma
Mantle Cell lymphoma (borderline between indolent and aggressive).

Question 2

What translocation confers worse response to H. pylori treatment of MALT lymphoma?

Answer 2

t(11;18)
Treat with radiation treatment or rituximab.
Otherwise treat H. Pylori MALT lymphoma by treating H. pylori.

Question 3

What mutations are seen in mantle cell lymphoma?

Answer 3

CyclinD1
SOX11

Question 4

Mantle Cell lymphoma
CD5
CD20
CD23

Answer 4

Mantle Cell lymphoma
CD5 +
CD20 + (bright)
CD23 -

Question 5

CLL/SLL
CD5
CD20
CD23

Answer 5

CLL/SLL
CD5 +
CD20 + (dim)
CD23 +

Question 6

STiL trial showed PFS benefit with this regiment compared to R-CHOP for indolent NHL

Answer 6

Bendamustine-Rituximab

Question 7

Follicular lymphoma - progression of disease is most important prognostic factor within what time frame?

Answer 7

24 months

Question 8

Splenic Marginal Zone Lymphoma associated with what infection?

Answer 8

HCV
HCV + - treat HCV
HCV - - treat with splenectomy or rituximab

Question 9

Autoimmune mediated anemia in CLL may be due to one of two etiologies.

Answer 9

Autoimmune hemolytic anemia or pure red cell aplasia.

Question 10

Most favorable prognosis in CLL.

Answer 10

13q deletion

Question 11

Preferred BTK inhibitors for CLL/SLL.

Answer 11

Acalabrutinib
Zanubrutinib

Question 12

Richters Transformation is CLL to what two possible histologies?

Answer 12

DLBCL
Classic Hodgkin Lymphoma

Question 13

First line CLL treatment, , good PS, no 17p deletion

Answer 13

R-FC
Rituximab, Fludarabine, Cyclophosphamide

Question 14

Poor prognosis cytogenetics for CLL

Answer 14

del11q, del17p, IgVH unmutated status

Question 15

First line CLL treatment, poor performance status

Answer 15

Chlorambucil and obinutuzumab

Question 16

First line CLL treatment, , good PS, 17p deletion

Answer 16

alemtuzumab followed by reduced intensity allo-SCT