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Pathobiology of Neoplasia > Lung Cancer > Flashcards

Flashcards in Lung Cancer Deck (15):
1

What are the 2 types of Lung ca?

Small Cell (15%)
Non-small Cell (85%)

2

What are the subtypes of NSCLC?

1. Adenocarcinoma (40%)
2. Squamous cell carcinoma
3. Large cell carcinoma

3

In what part of the lung is Lung Adenocarcinoma usually located?

Peripheral regions
Increased occurrence d/t cigarette filters which cause deeper inhalation

4

In what part of the lung is SCC usually located?

Central region of the lungs

5

What is limited stage SCLC?

30% of SCLC cases
Located on 1 side /1 lung
Can include nodes above
Can be tx'd with 1 XRT portal

6

What is extensive stage SCLC?

70% of SCLC cases
Mets outside of originating lung
Must be treated with >1 XRT field

7

Characteristics of SCLC

More aggressive
Rapid doubling time
High growth fraction
Early, widespread mets
Large hilar mass
Bulky CENTRAL adenopathy

8

SCLC often presents with?

Paraneoplastic syndromes
-ACTH (cushings syndrome)
-ADH (hyponatremia )

9

What is a Pancos tumor and presentation?

Also called superior sulkis tumor
High apical tumor; invades brachial plexus
1. Upper shoulder, back, chest pain
2. Facial weakness

10

Treatment of NSCLC

Surgery
XRT
Chemo
Targeted therapy

11

Types of surgery

Lobectomy
Pneumonectomy
Seg/Wedge
VATS

12

Targeted Therapy types for NSCLC

EGFR (often present in adenocarcinoma)
VEGF (Avastin w/ chemo)

13

Treatment for SCLC

Limited SCLC- Chemo and XRT
-better cure rate
Extensive SCLC-Chemo
-responsive but relapse is common
-cure is rare

14

Common sites for metastasis of lung cancer

1. Regional nodes
2. Lung
3. Bone
4. Adrenal
5. Liver
6. Brain

15

Lung cancer stats

1.3mil diagnosed every year
1.4mil deaths