Skin Cancers Flashcards Preview

Pathobiology of Neoplasia > Skin Cancers > Flashcards

Flashcards in Skin Cancers Deck (26):
1

What is located in the dermis?

Capillaries & Arterioles
Cutaneous appendages, pilary complexes, sebaceous glands, apocrine and epocrine glands

2

What is leukoplakia?

Raised white patches of mucous membranes
Will not wipe off like thrush
Located on lower lip, oral mucosa and vulva

3

What is erythroplakia?

Red patches of mucous membrane
91% lead to cancers

4

What is Bowen's disease?

Erythematous plaques
Resembles bcc
May turn in to SCC with high rate of mets

5

What is arsenical keratosis?

Skin lesions r/t increased arsenic intake
Usually on soles and palms

6

What is solar keratosis?

Also known as actinic keratosis
Result of cumulative effects of uv light
Usually turns into SCC with a low rate of mets

7

Which UV light causes the most damage?

UVB

8

What is primary prevention for skin cancer?

Sunscreen use with spf 15-20
Apply 15-30min before
Reapply every 90 minutes and after toweling off

9

What is keratin?

Fibrous protein in epidermis
Absorbs photons in UVA and UVB light

10

What is melanin?

Brownish black pigment in epidermis
Blocks and Scatters uv light and turns it into heat

11

Describe effect of ozone layer

Absorbs UVB
Filters UVC
When ozone layer decreases UVB penetration increases

12

Predisposing factors for SCC and BCC?

Albinism
Xeroderma pigmentosum
Chronic radiodermatitis
BCC ONLY: Arsenic intake

13

Which skin cancer is the most common?

BCC

14

What is the most common type of BCC?

Noduloulcerative
-translucent, pearly nodules with telangiectic lesions
-central areas of ulceration

15

Second most common type of BCC

Superficial BCC
-scaling, erythemic patches
-superficial ulceration

16

What is a rare type of BCC?

Sclerosing or morphea-like
White indurated lesions
Deeply invasive

17

What are the ABCDE of melanoma?

Asymmetry
Border
Color (mixed, black, blue, brown)
Diameter (>6mm)
Elevation

18

What is the most common type of melanoma?

Superficial spreading melanoma

19

Characteristics of superficial spreading melanoma

Most common type; 70%
Occurs in younger age group
Usually in upper back

20

Characteristics of Lentigo Maligna melanoma

Common in elderly
Starts as tan macular lesions
Turn brown, black, then invade and mets

21

Characteristics of melanoma on the mucous membrane

Common in blacks and Asians
Worse prognosis r/t later diagnosis

22

Breslow's classification

Measured in millimeters
Distance from epidermis to deepest identifiable layer of MM cells

23

What is the degree of inflammatory response?

Lymphocytic infiltration into the tumor area
Associated with a better prognosis

24

Characteristics of dysplastic Nevus syndrome

Genetic
MM begins earlier in life
Higher survival rate

25

Characteristics of head and neck cancer

Usually in epidermal layer or mucous membrane
Hpv tumors have better prognosis

26

Describe basal cells

Cuboidal or columnar cells
Located in epidermis