A patient who underwent a lung transplant is experiencing rejection. A biopsy is shown below. What is the condition called? Describe the process.
Obliterative bronchiolitis; Bronchiole is virtually entirely obliterated by concentric fibrosis
What condition is common in long-term lung transplant survivors? Cause?
Bronchiectasis probably due to poor perfuse, denervation, and recurrent airway infection
What are the most common fungal pneumonias in those with lung transplants? Viral?
Candida and Aspergillus; CMV
In patients who survive > 30 days 3-8% develop what disorder? Describe pathogenesis
Lymphoproliferative disorders owing to uncontrolled proliferation of EBV-infected lymphocytes as a result of immunosuppression by cyclosporine