Lymph/Lymphomas

Question 1

Leukemia involves what organs

Answer 1

bone marrow and peripheral blood

Question 2

Lymphomas involve what organs

Answer 2

Lymph nodes and other organs

Question 3

Hepatitis C virus predisposes you to which cancer

Answer 3

Splenic Marginal zone Lymphoma and Lymphoplasmacytic lymphoma

Question 4

What area of the lymph node are T cells normally found?

Answer 4

paracortical area

Question 5

What area of the lymph node are B cells normally found?

Answer 5

secondary lymphoid follicle

Question 6

What markers indicate precursor B cell

Answer 6

CD19*, CD34, TdT

Question 7

What markers indicate mature B cell

Answer 7

CD19, CD20, CD22, SIg

Also PAX5

Question 8

What markers indicate a plasma cell

Answer 8

CD138*, CIg

Question 9

What marker indicates a T cell

Answer 9

CD3

Question 10

What is the marginal zone made up of?

Answer 10

Memory B cells

The marginal zone is outside the mantle zone

Question 11

What is the function of BCL2?

Answer 11

anti apoptotic

Question 12

What is the main translocation for Burkitt Lymphoma?

What grade is it

Answer 12

8;14

high grade

Question 13

What is the translocation for Follicular lymphoma?

What grade is it

Answer 13

14;18

low grade

Question 14

What is the translocation for Mantle cell lymphoma

Answer 14

11;14 q13,q32

Translocation of IgH to the cyclin D1 gene –> uncontrolled cell cycle

Question 15

Which Hodgkins lymphoma has collagen bands surrounding a node

Answer 15

Nodular Sclerosis HL

Question 16

What does Brentuximab Vedotin treat?

Answer 16

resistant HL

- anti CD30 and Ab –> now added to chemotherapy

Question 17

Nivolumab and Pembrolizumab MOA

Answer 17

block PD1 and result in prolonged tumor rejection in HL

• antibodies
• cause an immune response

Question 18

Ibrutinib

Answer 18

tyrosine kinase inhibitor (block BTK)

treat CLL

Question 19

venetoclax

Answer 19

BCL2 inhibitor

promotes apoptosis to treat CLL

Question 20

Plasma cell description

Answer 20

terminally differentiated and non dividing B cells

- produce Ab

Question 21

Hallmark of Plasma cell disorder

Answer 21

paraprotein (overproduced IgG) in the serum or urine

Question 22

What does IL6 generate that contributes to cancer development

Answer 22

inhibit apoptosis, osteoclasts stimulation

Question 23

What do you add to MRI to see spinal cord compression

Answer 23

gadolinium contrast

Question 24

What do you use to treat myeloma?

Answer 24

lenalidomide, pomalidomide

Question 25

What does Daratumumab treat and target?

Answer 25

CD38 and plasma cell myeloma

Question 26

What does Bisphosphonate do? What is a major side effect?

Answer 26

inhibit osteoclasts and treat PCM osteonecrosis of jaw

Question 27

MYD88

Answer 27

when inhibited, decrease in NFkB (Ibrutinib)

Question 28

What is the limiting factor in bone marrow transplants

Answer 28

bone marrow toxicity

Question 29

What is the dose response of alkylating agents

Answer 29

steep | - inc dose = inc response

Question 30

Autologous Transplant

Answer 30

uses patients own stem cells for a transplant - eliminate all tumor cells with high dose chemo - doesn't need immunosuppressive

Question 31

CD34 marks what?

Answer 31

Hematopoietic progenitor stem cells

Question 32

Filgrastim and plerixafor do what?

Answer 32

Improve release of stem cells from bone marrow --> collection of stem cells from blood

Question 33

Common cause of transplant failure

Answer 33

Disease relapse

Question 34

Graft vs. Host disease what are the acute target organs what does it resemble chronically

Answer 34

donor T cells attack recipient Skin, gut, liver chronic: Sjogrens syndrome

Question 35

Treating Graft vs. Host disease

Answer 35

Cyclosporine/Tacrolimus and Methotrexate - Ruxolitinib = dec inflammatory cytokines

Question 36

Tocilizumab

Answer 36

can block IL6 response from CAR-T activation/use