Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

lymphoreticular pathology > lympho > Flashcards

lympho Flashcards

1
Q

Non hodgkin

A

Haphazard mode of spread
Leukemia phase
Involves extranodal sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Secondary site of production of lymphocytes

A

Lymph node
spleen
peyer’s patches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Tertiary lymphoid organs

A

Acquired lymphoid tissues in stomach, skin, respiratory and reproductive tracts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

major cells in cortex of lymph node

A

B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

major cells in paracortex

A

T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

implication of expansion of paracortex

A

CMI response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

majority of T cells are CD4+

True or false

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which cells do medullary cordds contain

A

Transformed lymphoid cells and plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

lypmphocytes from circulation enter node via

A

high endothelial venules in paracortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

do follicles in newborn have germinal centres

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

where does lymph eventually drain to

A

thoracic duct and SVC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

LAP anatomical site and disease

Post auricular node
occipital nodes
post cervical nodes
axillary node

A

Rubella
Scalp infections
toxoplasmosis
infection of arm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

type of lymphadenopathy in TB

A

Granulomatous lympadenitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Suppurative granulomatous LAP seen in

A

LGV

Cat scratch disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

types of reactive hyperplasia

A

Follicular hyperplasia
Paracortical expansion
sinus histiocytosis
dermatopathic lymphadenopathy(xterised by lipomelanic reticulosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Sinus histiocytosis with massive lymphadenopathy(Rosai-Dorfman syndrome)

A

febrile disease in children and young adults. bilateral cervical LAP. some patients have immune deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

kikuchi disease

A

necrotizing histiocytic
SLE like disease
cervical LN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

AIDS related LAP

A

Severe follicular hyperplasia
- Regressive follicular hyperplasia
- Follicular involution, progressing to
lymphocyte depletion. Helper T-cells are reduced and suppressor T-cells are increased in the germinal centres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

which malignant lesions may seen in AIDS

A

Kaposi sarcoma
HL
NHL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

On what basis do we classify lymphomas as HL Or NHL

A

presence or absence of Reed-Stenberg cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

lymphomas may be only nodal

A

false

can be extranodal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Apart from R-S cells, which other cells can be found in HL

A

Lacunar cells
Lymphocytic cells
Histiocytic(popcorn)
Hodgkin cell

23
Q

Hodgkin lymphoma

A

tumor of germinal centre B - cell with non-productive Ig gene arrangements

24
Q

Characteristic giant cell in HL

A

H-RS cell

25
Q

Characteristic giant cell in NLPHL(nodular lymphocyte predominant hodgkin lymphoma)

A

L and H cell

it is a type of Hodgkin lymphoma but not a classical one.

mature b cell lymphoma

26
Q

term given to how or why HRS cell escape apoptosis

A

fail to undergo negative selection

27
Q

role of NFKB in HL pathogenesis

A

upregulates pro-proliferative and anti-apoptotic gene expression programme in lymphocytes in inflammation

28
Q

which gene is highly mutated in HL and what’s its function

A

A20

regulates activity of NFKB

29
Q

Is A20 mutatiion only found in HL

A

No

also in DLBCL
Extranodal MZL

30
Q

Mechanisms by which HRS cells are resistant to apoptosis

A 
expression of CFLIP (antiapoptic protein)
inhibition of caspase 8 cleavage
a20 mutation
lack b cell receptor
lineage promiscuity
more in monozygotic twins
31
Q

role of EBV

A

Via LMPS- latent membrane proteins
2 - shuts down BCR expression
1 - leads to NFKB activation. 2 can do same.
this upregulation inhibits fas signalling

32
Q

key difference between NLPHL and HRS

A

HRS cells of CHL lack Bcl-6 proteins

33
Q

what HRS cells secrete

A

TH 2 cells cytokines and chemokines

34
Q

Classification of HL

A

Nodular sclerosis
mixed cellularity
lymphocyte depleted
lymphocyte rich

35
Q

nodular sclerosis

A

predilection for mediastinal lymph nodes
dominated by lacunar cells
graded 1 and 2 with 2 being worse

36
Q

mixed cellularity

A

younger age

EBV+

37
Q

Lymphocyte depletion

A

previously diagnosed as anaplastic carcinomas or high grade NHLs

HIV+
Aggressive but curable

38
Q

lymphocyte rich

A

no eosinophils
rare
ebv negative

39
Q

Staging of Hodgkin lymphoma

A

I – A single lymph node or a single extralymphatic organ
II- 2 or more groups of lymph nodes on the same side of diaphragm or localized involvement of an extralymphatics organ or site(IIE)
III- Lymph nodes on different side of diaphragm without or with involvement of an extralymphatic organ or site (IIIE)
IV- Diffuse involvement of 1 or more extralymphatic organs or sites with or without lymphatic involvement

40
Q

Etiology of NHL

A 
Congenital and acquired immune state
Ebv
T cell leukemia
GMZL
H pylori
Sunlight
EM field
Herbs, pesticides
Hep C virus
Hair dressing
Petrochemicals
41
Q

2 types of lymphoid leukemia

A

B cell acute or lymphoblastic leukemia or lymphoma

T cell acute or lymphoblastic leukemia or lymphoma

42
Q

Follicular lymphoma in gastric biopsy

A

CD 10

Bcl 2

43
Q

Which sites does Burkitt Lymphoma usually affect

A

Jaw

Abdominal organs

44
Q

What two factors govern the geographical distribution of BL

A

Temperature… Over 60F 15.5C

Humidity…. High

45
Q

BL Belt

A

10 15 N S equator

46
Q

Where is BL rare

A

High land
Dry arid area
Cold area

47
Q

Etiology of Burkitt Lymphoma

A

EBV infects B cells and nasopharyngeal epithelium.
T cell immunity required for control of EBV infection.

Deficiency in t cell immunity
Malaria… T cell immunodeficiency
Translocation of cmyc oncogene

48
Q

Translocation of cmyc oncogene

A

8 14
8 22
2 8

49
Q

Clinical presentation of BL

A

Jaw more in maxilla than mandible
Abdominal mass
CNS
Other organs repro thyroid kidneys

49
Q

Clinical presentation of BL

A

Jaw more in maxilla than mandible
Abdominal mass
CNS
Other organs repro thyroid kidneys

50
Q

Appearance in histology

A

Starry sky appearance

51
Q

Markers in BL

A

CD 20
CD 10
Ki67
Negative for bcl2

52
Q

Indolent disease Ema Positive with pop corn cells and respond to local chemotherapy

A

NLPHL

53
Q

Staging of BL

A

A - single extra abdominal mass
B - Multiple extra abdominal mass
C - Abdominal mass with or without facial tumor
D - Abdominal mass with sites of tumor other than facial or bone marrow
AR - Abdominal mass with >90 of tumor resected

lymphoreticular pathology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions