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lymphoreticular pathology > RENAL PATHOLOGY > Flashcards

RENAL PATHOLOGY Flashcards

1
Q

3 layers of glomerulus

A

EC
GBM
Podocytes

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2
Q

how many pyramids

A

12

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3
Q

renal lobe

A

medullary pyramid and overlying cortex

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4
Q

major compartments of glomerulus

A

Glomerular tuft

extraglomerular tuft

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5
Q

what are the four resident cell types in glomerulus

A

mesangial cells
endothelial cells
visceral epithelial cells/ podocytes - gt
parietal epithelial cells/ egt

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6
Q

Biochemical components of GBM

A 
Collagen Type 4
Laminin
Polyanionic proteoglycans
Fibronectin 
Entactin
Collagen 5 7
Amyloid P
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7
Q

Function of mesangium

A

Surface receptors for angiotensin 2,vasopressin, TXA2, PGE2
Alter glomerular capillary diameter and helps in regulating plasma blood flow
Participate in the Sequestration and clearing of immune complexes since they’ve abundant lysosomes

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8
Q

Components of JGA

A

Macula densa
Afferent arterioles terminal
Efferent arteeioles proximal
Macula densa

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9
Q

Types of renal hypoplasia

A

Oligomeganeohronic

Simple

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10
Q

Types of cystic renal dysplasia

A

Multicystic dysplasia
Localized dysplasia
Dysplasia associated with lower urinary tract obstruction

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11
Q

Complications of multicystic dysplasia

A

Nephroblastoma

RCC

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12
Q

Congenital nephronomegaly is associated with which syndrome

A

Beckwith-Wideman syndrome

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13
Q

Types of ectopic kidney

A

Simple or crossed

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14
Q

Horseshoe kidney associated with which syndrome

A

Turner syndrome

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15
Q

3 categories of RPGN

A
  1. Post infectious RPGN secondary to acute poly step GN
    Systemic diseases like Goodpasture syndrome, SLE, PAN, Wegener granulomatosis, Henoch-Schonlein purpura
  2. Idiopathic RPGN
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16
Q

How GP arise

A

spontaneously or follow influenza or exposue to organic solvents or drugs such as rifampicin

17
Q

renal manifestation of Goodpasture. Nephritic or nephrotic

A

Nephritic

18
Q

which two diseases present as asymptomatic haematuria

A

thin membrane disease

IgA nephropathy

19
Q

heterezygous mutatuion of COL4A3 COL4A4

Homozygous mutation

A

TMD

Alport syndrome

20
Q

do TMD patients develop Renal failure

A

no

21
Q

cause of death in Good pasture

A

uraemia

22
Q

distinguish between fibrillary GN and immunotactoid glomerulopathy

A

glomerular infiltration by fibrils

glomerular deposition of ig with structural organisation as microtubules

23
Q

lesions in dG

A

Glomerular lesions
Renal vascular aterio
Pyelonephritis
Tubular lesions

24
Q

what comprises the glomerular lesions in diabetic glomerulopathy

A

BM thickening
diffuse glomeruloscelois
nodular gs
exudative lesions(fibrin caps and capsular drops)

25
Q

which of the glomerula lesions is pathognomonic

A

Nodular glomeruloscelorosis

26
Q

where is Armani-Erbstein lesion found

A

proximal epithelial cells

Seen in diabetic glomerulonephropathy

27
Q

is diabetic neuropathy associated with proteinuria

A

yeah but it’s mild

28
Q

Conditions that predispose one to RCC

A

Von - Hippel Lindau Syndrome
Acquired cystic disease in pts on dialysis
ADPKD

29
Q

Most common RCC seen with dialysis associated cystic disease

A

Papillary carcinoma

30
Q

RCC may present in 3 ways. Name them

A

Autosomal dominant RCC with clear cell pattern
VHL
Papillary RCC

31
Q

In RCC, which percentage has Metatastis at time of diagnosis

A

1/3rd

32
Q

In RCC, where does it spread to

A

Perinephric fat
Regional lymph nodes

Lungs
Bones
Pelvis

33
Q

In RCC, where does it spread to

A

Perinephric fat
Regional lymph nodes

Lungs
Bones
Pelvis

34
Q

Clinical triad in RCC

A

Loin pain
Haematuria
Palpable tumor

35
Q

Angiomyolipoma is associated with which disease

A

Tuberous sclerosis

36
Q

Complication of angiomyolipoma

A

Retroperitoneal hemorrhage

lymphoreticular pathology (7 decks)

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