Lymphoid Pathology Infectious diseases

Question 1

What is the gross and histopathology of a virus in the thymus?

Answer 1

• Gross- haemorrhage/ oedema
• Histopathology- Decreased number of lymphocytes in all major organs (lobular collapse in the thymus)

Question 2

What is a notifiable virus for the thymus?

Answer 2

Classical Swine Fever

Question 3

What are some important viruses in the pig industry?

Answer 3

• African Swine Fever (splenomegaly)
• Porcine circovirus

Question 4

What is the gross pathology of haematropic bacteria?

Answer 4

Splenomegaly and Icterus

Question 5

What is the histopathology of haematropic bacteria?

Answer 5

Congestion, erythrophagia, hemosiderosis (excessive amounts of iron in the tissues)

Question 6

What do Pyogenic bacteria incite?

Answer 6

Neutrophils

Question 7

What does the gross pathology of pyogenic bacteria look like?

Answer 7

Multifocal absesses, suppurative inflammation

Question 8

What does the histopathology of pyogenic bacteria look like?

Answer 8

Abcesses in chronic
fribroneutrophillic inflammation in acute

Question 9

What is a notifiable pyogenic bacterial disease?

Answer 9

Streptococcus equi.

Question 10

What is a notfiable granulomatous bacterial disease?

Answer 10

Rhodoccoccus equi.

Question 11

What is the gross pathology of granulomatous bacteria?

Answer 11

Granulomatous inflammation (just very hard)

Question 12

What is another word for Mycobacterium avium ssp. paratuberculosis

Answer 12

Johne’s disease (notifiable in cattle)

Question 13

What is the histopathology of infectious bacteria?

Answer 13

Multinucleated giant cells, granulomas (central core of necrosis?)

Question 14

What would a spleen with Bacillus Anthracis look like?

Answer 14

Bloody spleen

Question 15

What may caseous lymphadenitis look like?

Answer 15

caseous lymph nodes

Question 16

What is the overview of how fungi affect the gross pathology?

Answer 16

• Meaty spleen
• Granulomatous inflammation

Question 17

What is the histopathology of how fungi affects an organ?

Answer 17

Fungal structures
Cells full of Yeast
Granulomatous inflammtion

Question 18

What is the gross pathology of protozoa?

Answer 18

• Meaty Spleen, splenomegaly, lympadenomegaly
• Granulomatous inflammation
• oedema/ haemorrhage

Question 19

What is the histopathology of protozoa?

Answer 19

Granulomatous inflammtion with intralesional organisms
Lymphoid hyperplasia with systemic infections
lymphoid atrophy

Question 20

What does babesia protozoa cause?

Answer 20

Splenic congestion, Icterus, anemia, hemoglobinuria

Question 21

What is the usual gross pathology of autoimmune diseases?

Answer 21

Splenic congestion, icterus, anemia, lympadenomegaly

Question 22

What is the usual histopathology of autoimmune diseases?

Answer 22

• Follicular hyperplasia
• Bone marrow can either be depletion or hyperplasia
• Splenic histiocytosis

Question 23

What is the overview of neoplastic lymphoma?

Answer 23

• Most common haemotologic malignancy in dogs
• Classified due to its anatomical location

Question 24

What is the gross pathology of neoplastic lymphoma?

Answer 24

Enlargement of organ- megaly (thickening of the intestines)
Pale tan nodules that bulge on the cut section

Question 25

What is the histopathology of neoplastic lymphomas?

Answer 25

* Proliferation of lymphocytes (either monomorphic or pleomorphic) * You can use nuclear size and mitotic count to determine the type of lymphoma

Question 26

What is PARR used for/ used to determine?

Answer 26

used for lymphomas to confirm clonality

Question 27

What are the common antibodies that an IHC will pick up to test for a T Cell?

Answer 27

CD3+

Question 28

What are the common antibodies that an IHC will use to test for a B cell?

Answer 28

CD20+, CD79a+

Question 29

What type of Virus is Feline Leukemia virus?

Answer 29

Gammaretrovirus

Question 30

What are the disease syndromes of feline leukaemia virus?

Answer 30

neoplasms, bone marrow supression, neurologic disorders

Question 31

What organs does bovine leukemia virus commonly affect?

Answer 31

Lymph nodes, abomasum, heart, spinal cord, kidney, uterus

Question 32

What may a splenic neoplasia Hemangiosarcoma look like histologically?

Answer 32

endothelial cells produce poorly formed vascular areas

Question 33

What is the overview of SCID?

Answer 33

* Developmental disease * Deficiency in B cells and or T cells * Most common in arabian horses (mutation in DNA-PKcs gene)

Question 34

What is the gross pathology of SCID?

Answer 34

small thymus, spleen- hyperplasia

Question 35

What is the histopathology of SCID?

Answer 35

Decreased or absent T cells and or B cells in lymphoid tissues (hypoplasia)

Question 36

What other disease is SCID commonly associated with?

Answer 36

Bronchopneumonia

Question 37

What do siderotic plaques look like grossly?

Answer 37

grey-white to yellow, firm, dry encrustations multifocally scattered across the splenic capsule

Question 38

What do siderotic plaques look like histologically?

Answer 38

Capsular deposits of billirubin, hemosiderin, hematoidin and/or calcium

Question 39

What does streptococcus equi cause?

Answer 39

Strangles

Question 40

What does rhodococcus equi cause?

Answer 40

pyrogranulomatous lymphadenitis