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Pom 2 > Lymphoid tissues 2 > Flashcards

Lymphoid tissues 2 Flashcards

1
Q

What 2 things is the lymphatic system comprised of?

A

Lymphatic vessels and secondary lymphoid tissue

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2
Q

What is lymphoid tissue comprised of?

A

Primary, secondary, tertiary

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3
Q

What happens in primary lymphoid organs?

A

Lymphopoiesis

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4
Q

What are 3 primary lymphoid organ?

A

Thymus
Bone marrow
Fetal liver

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5
Q

What are the 3 lymphocytes?

A

B cells
T cells
Natural Killer cells

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6
Q

What cells is the adaptive immune response comprised of?

A

B and T cells

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7
Q

What are the 2 hallmarks of the adaptive immune response and describe them?

A

Specificity – provided by a vast range of unique T cell and B cell receptors

Memory – rapid expansion in response to secondary encounter

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8
Q

What bones does hematopoiesis most occur in in adults?

A

Flat bones, but also vertebrae and ends of long limb bones

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9
Q

What does repertoire mean?

A

The range of genetically distinct BCRs or TCRs present in a given host

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10
Q

Where do B cells undergo final differentiation (repertoire generated)?

A

Bone marrow

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11
Q

Where does final maturation of B cells occur?

A

The periphery

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12
Q

Where are immature T cells produced?

A

Bone marrow

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13
Q

Where do T cells mature?

A

The thymus

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14
Q

What are the 2 types of selection T cells undergo?

A

Positive and negative selection

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15
Q

What is positive selection?

A

T cell is asked whether it can recognise an antigen

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16
Q

What is negative selection?

A

Tests if it reacts against our own body

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17
Q

What happens to T cells that fail the selection?

A

Apoptosis

18
Q

What is thymic involution?

A

The shrinking of the thymus with age

19
Q

What is thymic involution associated with?

A

Change in structure and reduced mass

20
Q

Does T cell output increase or decrease with age?

A

Decrease

21
Q

Does thymus get more or less fatty with age?

A

More fatty

22
Q

How many TCR sequences per T Cell?

A

1

23
Q

How many TCR sequences do genes allow for?

A

10^15- 10^20

24
Q

How many T cells do we have?

A

3.75x10^11

25
Q

What happens at secondary lymphoid tissues?

A

Lymphocytes interact with antigens and other lymphocytes

26
Q

Name 4 secondary lymphoid organs

A

Spleen
Lymph nodes
Appendix
Mucosa-associated lymphoid tissue

27
Q

How are lymphoid tissues interconnected?

A

Via lymphatic system and the blood

28
Q

Why are lymphoid tissues beneficial?

A

Bring cells in close proximity to antigen

29
Q

Do lymph nodes have distinct regions for B and T cells?

A

Yes

30
Q

What are the 2 categories of lymphatic vessels in lymphatic tissue?

A

Afferent and efferent

31
Q

What is the first line of defence against infection

A

Epithelial barriers

32
Q

What type of barrier is an epithelial barrier?

A

A physical barrier

33
Q

What type of lymphoid tissue is located in the gut and what is it called?

A

Specialized secondary lymphoid tissues called Peyer’s patches

34
Q

Where exactly are Peyer’s pathes found?

A

Below the epithelium of the ileum of the small intestine.

35
Q

What are Peyer’s patches enriched with?

A

Germinal centres

36
Q

What are the 4 types of tonsils?

A

Pharyngeal, tubular, palantine and lingual

37
Q

What ring do the 4 types of tonsil create?

A

Waldeyer ring

38
Q

How often does each naïve T cell recirculate?

A

Once every 24 hrs

39
Q

What is the purpose of dendritic cells?

A

Antigen presentation

40
Q

What are the two types of dendritic cells in relation to movement?

A

Tissue resident and migratory

41
Q

How do DC migrate into lymph nodes?

A

Via the afferent lymph into lymph nodes

Pom 2 (5 decks)

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